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Dietary Grape-Seed Procyanidins Decreased Postweaning Diarrhea by Modulating Intestinal Permeability and Suppressing Oxidative Stress in Rats
- Source :
- Journal of Agricultural and Food Chemistry. 59:6227-6232
- Publication Year :
- 2011
- Publisher :
- American Chemical Society (ACS), 2011.
-
Abstract
- This study was conducted to evaluate the effects of grape-seed procyanidins in controlling weaning diarrhea using a rat model. Weaned rats were fed either the basal diet or basal diet supplemented with either 250 mg/kg grape-seed procyanidins or 2000 mg/kg ZnO. Treated rats had better performance with a reduced incidence of diarrhea (P < 0.05). Both ZnO and grape-seed procyanidins significantly reduced urinary lactulose to mannitol ratios (P < 0.05) and enhanced the mRNA and protein expression of the intestinal mucosal tight junction proteins Ocln/ZO-1 (P < 0.05). Grape-seed procyanidins increased the activities of SOD, GSH-Px, and GSH while decreasing the level of MDA in the intestinal mucosa (P < 0.05). Furthermore, an in vitro investigation revealed that supplementation with grape-seed procyanidins in IEC-6 intestinal epithelial cells significantly enhanced the expression of Ocln/ZO-1 under H(2)O(2)-induced oxidative stress. Collectively, these results indicate that grape-seed procyanidins have the potential to prevent weaning diarrhea by reducing intestinal permeability and improving antioxidant indices.
- Subjects :
- Diarrhea
Male
medicine.medical_specialty
Cell Membrane Permeability
Antioxidant
medicine.medical_treatment
Down-Regulation
Biology
medicine.disease_cause
Cell Line
Rats, Sprague-Dawley
chemistry.chemical_compound
Lactulose
Intestinal mucosa
Internal medicine
medicine
Animals
Humans
Weaning
Proanthocyanidins
Vitis
Intestinal Mucosa
Intestinal permeability
food and beverages
General Chemistry
Glutathione
medicine.disease
Rats
Oxidative Stress
Endocrinology
chemistry
Biochemistry
Dietary Supplements
Seeds
Mannitol
General Agricultural and Biological Sciences
Oxidative stress
medicine.drug
Subjects
Details
- ISSN :
- 15205118 and 00218561
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Journal of Agricultural and Food Chemistry
- Accession number :
- edsair.doi.dedup.....9eeba40cfda79921466f1e30ada341df
- Full Text :
- https://doi.org/10.1021/jf200120y