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Expression of connective tissue growth factor (CTGF/CCN2) in a mouse model of rhabdomyosarcomagenesis
- Source :
- Scopus-Elsevier
- Publication Year :
- 2007
-
Abstract
- Connective tissue growth factor (CTGF/CCN2) is a cysteine-rich matricellular protein that belongs to the CCN (CYR61, CTGF, NOV) protein family. It is highly expressed by human rhabdomyosarcoma cells and sustains their survival. In this study we investigated CCN2 expression in a mouse model of spontaneous rhabdomyosarcomagenesis that combines HER-2/neu oncogene activation and p53 oncosuppressor gene inactivation (BALB-p53neu mice). Murine rhabdomyosarcoma cells showed a 4-26 fold increase in CCN2 mRNA expression regarding to normal thigh muscle. Moreover, they expressed CCN2 protein at levels comparable to human rhabdomyosarcoma cells. Therefore BALBp53neu mice might be useful for the evaluation of the role played by CCN2 in rhabdomyosarcoma in vivo.
- Subjects :
- Male
Cancer Research
Protein family
medicine.medical_treatment
Connective tissue
Gene Expression
Biology
Pathology and Forensic Medicine
Immediate-Early Proteins
Mice
Nephroblastoma Overexpressed Protein
Gene expression
Rhabdomyosarcoma
medicine
Animals
Mice, Inbred BALB C
integumentary system
Growth factor
Matricellular protein
Connective Tissue Growth Factor
General Medicine
medicine.disease
CTGF
Disease Models, Animal
medicine.anatomical_structure
Oncology
CYR61
Cancer research
Intercellular Signaling Peptides and Proteins
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier
- Accession number :
- edsair.doi.dedup.....9ef38134e4abdb875210656f988c6b8c