Back to Search Start Over

Expression of connective tissue growth factor (CTGF/CCN2) in a mouse model of rhabdomyosarcomagenesis

Authors :
Pier Luigi Lollini
Stefania Croci
Arianna Palladini
Carla De Giovanni
Giordano Nicoletti
Agnese Antognoli
Lorena Landuzzi
Patrizia Nanni
S. Croci
L. Landuzzi
G. Nicoletti
A. Palladini
A. Antognoli
C. De Giovanni
P. Nanni
P.L. Lollini.
Source :
Scopus-Elsevier
Publication Year :
2007

Abstract

Connective tissue growth factor (CTGF/CCN2) is a cysteine-rich matricellular protein that belongs to the CCN (CYR61, CTGF, NOV) protein family. It is highly expressed by human rhabdomyosarcoma cells and sustains their survival. In this study we investigated CCN2 expression in a mouse model of spontaneous rhabdomyosarcomagenesis that combines HER-2/neu oncogene activation and p53 oncosuppressor gene inactivation (BALB-p53neu mice). Murine rhabdomyosarcoma cells showed a 4-26 fold increase in CCN2 mRNA expression regarding to normal thigh muscle. Moreover, they expressed CCN2 protein at levels comparable to human rhabdomyosarcoma cells. Therefore BALBp53neu mice might be useful for the evaluation of the role played by CCN2 in rhabdomyosarcoma in vivo.

Details

Language :
English
Database :
OpenAIRE
Journal :
Scopus-Elsevier
Accession number :
edsair.doi.dedup.....9ef38134e4abdb875210656f988c6b8c