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New insights into vitamin D regulation: is there a role for alkaline phosphatase?
- Source :
- Journal of Endocrinological Investigation
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Purpose The diagnosis of vitamin D deficiency is based on the determination of total plasma 25-hydroxyvitamin D (25-OHD) concentrations, but the regulation of vitamin D 25-hydroxylation is not a major consideration and very little information is available on this activity. To check what factors could interfere with the activity of vitamin D-25-hydroxylase and thus alter the 25-OHD concentrations, we looked for potential correlations between 25-OHD and results of liver function tests in healthy adults. Methods This single-centre study was retrospective and consisted of evaluating the correlations between 25-OHD and the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), and bone alkaline phosphatase (BALP) in 349 healthy subjects aged from 18 to 65 years. In particular, in Group 1 (n = 119), we looked for correlations between 25OHD and all liver function tests and in Group 2 (n = 230) the correlation between 25OHD and BALP. Results In Group 1, we found no correlation between 25OHD and AST (r = − 0.03; p = 0.8), ALT (r = − 0.02; p = 0.91), GGT (r = − 0.08; p = 0.68), direct bilirubin (r = − 0.02; p = 0.89), indirect bilirubin (r = − 0.24; p = 0.21), and total bilirubin (r = − 0.24; p = 0.21) but one between 25OHD and ALP (r = − 0.2; p = 0.007); in Group 2, we found a significant negative correlation between 25-OHD and BALP (r = − 0.2; p = 0.0008). Conclusions The correlations that we found suggest that ALP and BALP might be involved in the regulation of vitamin D-25-hydroxylase activity, but further studies are mandatory to confirm our assumptions.
- Subjects :
- Adult
Male
Vitamin
medicine.medical_specialty
Adolescent
Bilirubin
Endocrinology, Diabetes and Metabolism
Direct bilirubin
25-Hydroxyvitamin D
030209 endocrinology & metabolism
Bone and Bones
vitamin D deficiency
Young Adult
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Liver Function Tests
Internal medicine
medicine
Vitamin D and neurology
Animals
Humans
Vitamin D
Aged
Retrospective Studies
030219 obstetrics & reproductive medicine
medicine.diagnostic_test
business.industry
Healthy subjects
25-Hydroxylase
Middle Aged
Alkaline Phosphatase
Vitamin D Deficiency
medicine.disease
chemistry
CYP2R1
Alkaline phosphatase
Original Article
Rabbits
Liver function tests
business
Subjects
Details
- ISSN :
- 17208386
- Database :
- OpenAIRE
- Journal :
- Journal of Endocrinological Investigation
- Accession number :
- edsair.doi.dedup.....9f1537e8c330138e6fec535b78842e67