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Global and Regional Changes in Cortical Development Assessed by MRI in Fetuses with Isolated Nonsevere Ventriculomegaly Correlate with Neonatal Neurobehavior
- Source :
- AJNR Am J Neuroradiol, AM J NEURORADIOL, r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu, Fundació Sant Joan de Déu, r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu, instname
- Publication Year :
- 2019
-
Abstract
- BACKGROUND AND PURPOSE: Fetuses with isolated nonsevere ventriculomegaly (INSVM) are at risk of presenting neurodevelopmental delay. However, the currently used clinical parameters are insufficient to select cases with high risk and determine whether subtle changes in brain development are present and might be a risk factor. The aim of this study was to perform a comprehensive evaluation of cortical development in INSVM by magnetic resonance (MR) imaging and assess its association with neonatal neurobehavior. MATERIALS AND METHODS: Thirty-two INSVM fetuses and 29 healthy controls between 26-28 weeks of gestation were evaluated using MR imaging. We compared sulci and fissure depth, cortical maturation grading of specific areas and sulci and volumes of different brain regions obtained from 3D brain reconstruction of cases and controls. Neonatal outcome was assessed by using the Neonatal Behavioral Assessment Scale at a mean of 4 ± 2 weeks after birth. RESULTS: Fetuses with INSVM showed less profound and underdeveloped sulcation, including the Sylvian fissure (mean depth: controls 16.8 ± 1.9 mm, versus INSVM 16.0 ± 1.6 mm; P = .01), and reduced global cortical grading (mean score: controls 42.9 ± 10.2 mm, versus INSVM: 37.8 ± 9.9 mm; P = .01). Fetuses with isolated nonsevere ventriculomegaly showed a mean global increase of gray matter volume (controls, 276.8 ± 46.0 ×10 mm3, versus INSVM 277.5 ± 49.3 ×10 mm3, P = .01), but decreased mean cortical volume in the frontal lobe (left: controls, 53.2 ± 8.8 ×10 mm3, versus INSVM 52.4 ± 5.4 ×10 mm3; P = < .01). Sulcal depth and brain volumes were significantly associated with the Neonatal Behavioral Assessment Scale severity (P = .005, Nagelkerke R2 = 0.732). CONCLUSIONS: INSVM fetuses showed differences in cortical development, including regions far from the lateral ventricles, that are associated with neonatal neurobehavior. These results suggest the possible use of these parameters to identify cases at higher risk of altered neurodevelopment. ispartof: AMERICAN JOURNAL OF NEURORADIOLOGY vol:40 issue:9 pages:1567-1574 ispartof: location:United States status: published
- Subjects :
- Male
medicine.medical_specialty
Pediatrics
Infant, Newborn, Diseases
030218 nuclear medicine & medical imaging
03 medical and health sciences
Lateral ventricles
0302 clinical medicine
Fetus
Risk Factors
Internal medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
Prospective Studies
Cerebral Cortex
medicine.diagnostic_test
business.industry
Infant, Newborn
Magnetic resonance imaging
medicine.disease
Mr imaging
Magnetic Resonance Imaging
Frontal lobe
Case-Control Studies
Cardiology
Gestation
Female
Neurology (clinical)
business
Neonatal behavioral assessment scale
030217 neurology & neurosurgery
Ventriculomegaly
Hydrocephalus
Subjects
Details
- ISSN :
- 1936959X and 01956108
- Volume :
- 40
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- AJNR. American journal of neuroradiology
- Accession number :
- edsair.doi.dedup.....9f1608dca33b6cc8da8b6035bca2990b