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Gonadotrophin-releasing Hormone Therapy in Hypogonadal Males with Hypothalamic or Pituitary Dysfunction
- Source :
- BMJ. 4:617-621
- Publication Year :
- 1974
- Publisher :
- BMJ, 1974.
-
Abstract
- Subcutaneous self-administration of synthetic gonadotrophin-releasing hormone 500 mug eight-hourly for up to one year by 12 male patients (five prepubertal) with clinical hypogonadism due to hypothalamic or pituitary disease resulted in the synthesis and continued release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). There was a rise in circulating androgen levels in all patients. Improvements in pubertal ratings were seen in some prepubertal patients. Potency returned in the adults and spermatogenesis was induced and maintained in the four patients who had received treatment for more than four months, total counts reaching between 7.8 and 432 x 10(6) spermatozoa. A fall in the FSH response to the releasing hormone occurred during spermatogenesis though LH was little affected. During the initial weeks of therapy FSH secretion usually occurred before that of LH though LH secretion was greater as treatment continued. FSH secretion also persisted for longer when treatment was stopped.
- Subjects :
- Adult
Male
endocrine system
medicine.medical_specialty
Adolescent
Pituitary disease
medicine.drug_class
Injections, Subcutaneous
Pituitary Diseases
Hypothalamus
Gonadotropin-releasing hormone
Gonadotropin-Releasing Hormone
Craniopharyngioma
Follicle-stimulating hormone
Internal medicine
Acromegaly
medicine
Humans
Testosterone
Spermatogenesis
General Environmental Science
Brain Diseases
Estradiol
Brain Neoplasms
business.industry
Hypogonadism
Puberty
General Engineering
Dihydrotestosterone
Papers and Originals
General Medicine
Luteinizing Hormone
medicine.disease
Androgen
Endocrinology
Growth Hormone
General Earth and Planetary Sciences
Serum Globulins
Follicle Stimulating Hormone
Luteinizing hormone
business
Protein Binding
Subjects
Details
- ISSN :
- 14685833 and 09598138
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- BMJ
- Accession number :
- edsair.doi.dedup.....9f17cff3bb50ce4c64213cd223e1df4b