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Hepatitis E outbreak in a mechanical factory in Qingdao City, China
- Source :
- International Journal of Infectious Diseases, Vol 86, Iss, Pp 191-196 (2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- Objective: In July 2018, recurrent hepatitis E cases were reported from a factory in Qingdao City, China. The aim of this study was to identify additional cases, and help prevent future incidents by identifying possible risk factors for infection. Methods: Participants were asked to provide blood samples for hepatitis E virus (HEV) IgM and IgG antibodies screening, as well as liver function test. A questionnaire that assessed demographics, potential risk factors, and clinical symptoms was completed by participants. HEV RNA genotyping was performed using a nested Reverse Transcriptional Polymerase Chain Reaction (RT-PCR) method. Adjusted Poisson regression model for participant characteristics and risk factors was constructed for multivariate analysis. Results: Overall, 41(14.5%, 41/283) participants had recent acute infection (21 of these were symptomatic). The result of multivariate analysis demonstrated a significant association of acute HEV infection with consumption of pig liver within the past two months (Relative Risk 2.61, 95% confidence interval (CI) 1.10–6.17, p = 0.0294). Sequencing of HEV RNA from seventeen acute cases indicated three HEV isolates of genotype 4 induced this outbreak. Conclusions: This was probably a common-source foodborne hepatitis E outbreak, related to the consumption of undercooked pig liver. Keywords: Hepatitis E, Foodborne diseases, Zoonoses
- Subjects :
- Adult
Male
0301 basic medicine
Microbiology (medical)
China
medicine.medical_specialty
Meat
Multivariate analysis
Swine
030106 microbiology
Food Contamination
medicine.disease_cause
Disease Outbreaks
lcsh:Infectious and parasitic diseases
Young Adult
03 medical and health sciences
symbols.namesake
0302 clinical medicine
Liver Function Tests
Manufacturing and Industrial Facilities
Hepatitis E virus
Risk Factors
Occupational Exposure
Surveys and Questionnaires
Internal medicine
medicine
Animals
Humans
lcsh:RC109-216
Hepatitis Antibodies
030212 general & internal medicine
Poisson regression
Genotyping
medicine.diagnostic_test
business.industry
Outbreak
General Medicine
Middle Aged
Hepatitis E
medicine.disease
Infectious Diseases
Relative risk
symbols
Female
Liver function tests
business
Subjects
Details
- Language :
- English
- ISSN :
- 12019712
- Volume :
- 86
- Database :
- OpenAIRE
- Journal :
- International Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....9f3adc61b50a97c806ed6120bbf3af46