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A rare case of granuloma annulare in a 5-year-old child with type 1 diabetes and autoimmune thyroiditis
- Source :
- The American Journal of dermatopathology. 35(3)
- Publication Year :
- 2012
-
Abstract
- Granuloma annulare (GA) has rarely been reported in childhood, and its etiology still remains unclear. Its association with type 1 diabetes (T1D) and other chronic systemic diseases such as autoimmune thyroiditis (AT) or rheumatoid arthritis has been reported. There is no description in the literature of pediatric cases and the simultaneous association of GA and multiple autoimmune diseases in the same subject. We report the case of a 5-year-old girl who presented onset signs and symptoms of T1D. The diagnosis of T1D was confirmed by the presence of autoimmune T1D antibodies. Moreover, AT was also diagnosed by autoantibodies and positive ultrasound. One month later, coin-size erythematous lesions appeared initially on the trunk but soon spread over the body. Once dermatophytosis had been excluded, a skin biopsy confirmed a diagnosis of GA. Although a clear mechanism remains still unknown, clinicians must take into consideration an association of GA in patients with T1D or AT to avoid unnecessary medical investigations and/or inadequate pharmacological treatment.
- Subjects :
- medicine.medical_specialty
endocrine system diseases
type 1 diabetes
Biopsy
Dermatology
Pathology and Forensic Medicine
Autoimmune thyroiditis
Diagnosis, Differential
Granuloma Annulare
children
Predictive Value of Tests
Medicine
Humans
granuloma
Granuloma annulare
Skin
Type 1 diabetes
medicine.diagnostic_test
business.industry
Autoantibody
Thyroiditis, Autoimmune
General Medicine
medicine.disease
Diabetes Mellitus, Type 1
Rheumatoid arthritis
Granuloma
Child, Preschool
Skin biopsy
Female
Differential diagnosis
business
Subjects
Details
- ISSN :
- 15330311
- Volume :
- 35
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- The American Journal of dermatopathology
- Accession number :
- edsair.doi.dedup.....9f40d08b80ebafabcd0d9f2dd765df2a