Back to Search
Start Over
Comparative pharmacodynamics and pharmacokinetics of methadone and slow-release oral morphine for maintenance treatment of opioid dependence
- Source :
- Drug and Alcohol Dependence. 72:85-94
- Publication Year :
- 2003
- Publisher :
- Elsevier BV, 2003.
-
Abstract
- Slow-release oral morphine (SROM) has been proposed as an alternative maintenance pharmacotherapy to methadone for treatment of opioid dependence. However, the pharmacodynamics and pharmacokinetics of SROM have not been previously assessed in a methadone maintenance population.In 14 methadone maintenance patients reporting adequate (holders, n=7) or inadequate (non-holders, n=7) withdrawal suppression between doses, plasma drug concentrations and indices of opioid effect (withdrawal severity, pupil diameter, and respiratory rate) were determined across a 24 h inter-dosing interval on one occasion at steady-state for methadone and SROM (once-daily Kapanol) using an open-label, crossover design.Opioid effects were of a similar overall magnitude following dosing for each drug and showed an inverse association with plasma drug concentrations, which peaked later for morphine compared to (R)-methadone (6.5 +/- 2.3 h vs. 2.5 +/- 1.4 h, P0.001). For methadone non-holders, the number of self-reported opioid withdrawal symptoms prior to dosing was less for SROM compared to methadone (3.4 +/- 2.6 vs. 9.0 +/- 3.2, P0.01); for holders it was approximately equal (4.4 +/- 3.0 vs. 4.0 +/- 3.7, P0.76). Maintenance doses were more strongly related to plasma drug concentrations for SROM compared to methadone and may thus be more predictive of therapeutic response for the former medication. Twelve of the 14 subjects preferred SROM to methadone (P=0.01).The pharmacodynamics and pharmacokinetics of SROM support its use as an alternative once-daily agonist option in the treatment of opioid dependence, particularly for patients responding poorly to methadone maintenance treatment.
- Subjects :
- Adult
Male
Methadone maintenance
Adolescent
Narcotic Antagonists
Population
Administration, Oral
Toxicology
Pharmacokinetics
Humans
Medicine
Pharmacology (medical)
education
Aged
Pharmacology
education.field_of_study
Cross-Over Studies
Morphine
business.industry
Middle Aged
Opioid-Related Disorders
Crossover study
Psychiatry and Mental health
Opioid
Delayed-Action Preparations
Pharmacodynamics
Anesthesia
Female
business
Methadone
medicine.drug
Subjects
Details
- ISSN :
- 03768716
- Volume :
- 72
- Database :
- OpenAIRE
- Journal :
- Drug and Alcohol Dependence
- Accession number :
- edsair.doi.dedup.....9f54d769a3aaf8fea58163cfcac2fc54