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Antimicrobial peptides in saliva of children with severe early childhood caries
- Source :
- Scopus, Repositório Institucional da UNESP, Universidade Estadual Paulista (UNESP), instacron:UNESP
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Made available in DSpace on 2018-12-11T17:02:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-09-01 Objective Controversies exist regarding the relationship between the concentrations of antimicrobial peptides (AMPs) and presence of dental caries in children. Thus, the aim of this study was to examine levels of AMPs in saliva of caries-free (CF), early childhood caries (ECC) and severe early childhood caries (S-ECC) children to determine if the levels of these salivary peptides individually or in combinations were related to caries severity and mutans streptococci levels. Design 36 to 60 month-old children were selected to participate in this study. Children were grouped into CF group (n = 29), ECC group (n = 25) and S-ECC group (n = 29). Saliva was collected from children for microbiological analysis by culture. Salivary concentrations of cathelicidin LL-37, human β-defensin 2 (hBD-2), human β-defensin 3 (hBD-3) and histatin-5 (HTN-5) were determined by ELISA. Results Salivary concentrations of AMPs did not differ among CF, ECC and S-ECC groups. Data showed positive correlations between mutans streptococci levels and salivary hBD-2 or HTN-5. Positive correlations were found between hBD-2, hBD-3, LL-37 and HTN-5. Combinations among AMPs, mainly LL-37, were positively associated with caries levels. Conclusions Salivary concentrations of AMPs individually were not associated with the severity of early childhood caries. The stimulus of caries appears to trigger a biological response, however, with a combination of these peptides. UNESP-Univ. Estadual Paulista Department of Pediatric Dentistry and Public Health Araçatuba Dental School, Rua José Bonifácio, 1193 Forsyth Institute Department of Microbiology Harvard University Harvard School of Dental Medicine UNESP-Univ. Estadual Paulista Department of Pediatric Dentistry and Public Health Araçatuba Dental School, Rua José Bonifácio, 1193
- Subjects :
- Male
0301 basic medicine
Saliva
beta-Defensins
Histatin-5
Human cathelicidin LL-37
medicine.medical_treatment
Antimicrobial peptides
Histatins
Dental Caries
Cathelicidin
Salivary Peptides
Streptococcus mutans
Defensins
03 medical and health sciences
0302 clinical medicine
Anti-Infective Agents
Cathelicidins
medicine
Humans
Salivary Proteins and Peptides
Children
General Dentistry
Innate immunity
biology
business.industry
030206 dentistry
Cell Biology
General Medicine
biology.organism_classification
medicine.disease
stomatognathic diseases
030104 developmental biology
Beta defensin
Otorhinolaryngology
Child, Preschool
Immunology
Dental caries
Female
business
Early childhood caries
Antimicrobial Cationic Peptides
Subjects
Details
- ISSN :
- 00039969
- Volume :
- 69
- Database :
- OpenAIRE
- Journal :
- Archives of Oral Biology
- Accession number :
- edsair.doi.dedup.....9f57763385632cde422c5c7ed65e5982