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New Thio-Compounds and Monoterpenes With Anti-inflammatory Activities From the Fungus
- Source :
- Frontiers in Microbiology, Frontiers in Microbiology, Vol 12 (2021)
- Publication Year :
- 2021
-
Abstract
- Two new thio-compounds named aspergerthinol A and B (1 and 2) and two new monoterpenes named aspergerthinacids A and B (3 and 4) were isolated from the fungus Aspergillus sp. CYH26 from the rhizosphere soil of Cynanchum bungei Decne. The structures of compounds were elucidated by spectroscopic data and quantum NMR and ECD calculations. Compounds 1 and 2 represented a new family of sulfur containing natural products with a 3-methyl-4H-cyclopenta[b]thiophen-4-one skeleton. Compounds 1–4 showed inhibitory activities against nitric oxide (NO) with IC50 values of 38.0, 19.8, 46.3, and 56.6 μM, respectively.
- Subjects :
- Microbiology (medical)
medicine.drug_class
Stereochemistry
lcsh:QR1-502
Thio
Fungus
Aspergillus sp. CYH26
01 natural sciences
Microbiology
Anti-inflammatory
lcsh:Microbiology
Nitric oxide
03 medical and health sciences
chemistry.chemical_compound
medicine
Ic50 values
anti-inflammatory activity
030304 developmental biology
Original Research
0303 health sciences
Rhizosphere
Aspergillus
biology
010405 organic chemistry
Cynanchum bungei
fungus
monoterpenes
biology.organism_classification
0104 chemical sciences
chemistry
thio-compounds
Subjects
Details
- ISSN :
- 1664302X
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in microbiology
- Accession number :
- edsair.doi.dedup.....9f6e6cf3c3605fd82c07e7522eae02ba