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NF-Y (CBF) regulation in specific cell types and mouse models
- Source :
- Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1860:598-603
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- The CCAAT-binding factor CBF/NF-Y is needed for cell proliferation and early embryonic development. NF-Y can regulate the expression of different cell type-specific genes that are activated by various physiological signaling pathways. Dysregulation of NF-Y was observed in pathogenic conditions in humans such as scleroderma, neurodegenerative disease, and cancer. Conditional inactivation of the NF-YA gene in mice demonstrated that NF-Y activity is essential for normal tissue homeostasis, survival, and metabolic function. Altogether, NF-Y is an essential transcription factor that plays a critical role in mammalian development, from the early stages to adulthood, and in human pathogenesis. This article is part of a Special Issue entitled: Nuclear Factor Y in Development and Disease, edited by Prof. Roberto Mantovani.
- Subjects :
- 0301 basic medicine
Cell
Biophysics
Biology
Biochemistry
Article
Pathogenesis
Mice
03 medical and health sciences
Structural Biology
Genetics
medicine
Animals
Humans
Molecular Biology
Transcription factor
Gene
Tissue homeostasis
Cell growth
Neurodegenerative Diseases
Neoplasms, Experimental
Neoplasm Proteins
Cell biology
030104 developmental biology
medicine.anatomical_structure
CCAAT-Binding Factor
Scleroderma, Diffuse
Signal transduction
Homeostasis
Subjects
Details
- ISSN :
- 18749399
- Volume :
- 1860
- Database :
- OpenAIRE
- Journal :
- Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- Accession number :
- edsair.doi.dedup.....9f840865dadda59737003fbfc293c7cf