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The evolution of the epidemiological landscape of head and neck cancer in Italy: Is there evidence for an increase in the incidence of potentially HPV-related carcinomas?

Authors :
Paolo Boscolo-Rizzo
Manuel Zorzi
Annarosa Del Mistro
Maria Cristina Da Mosto
Giancarlo Tirelli
Carlotta Buzzoni
Massimo Rugge
Jerry Polesel
Stefano Guzzinati
AIRTUM Working Group
Boscolo-Rizzo, Paolo
Zorzi, Manuel
Mistro, Annarosa Del
Da Mosto, Maria Cristina
Tirelli, Giancarlo
Buzzoni, Carlotta
Rugge, Massimo
Polesel, Jerry
Guzzinati, Stefano
BOSCOLO RIZZO, Paolo
Source :
PLoS ONE, Vol 13, Iss 2, p e0192621 (2018), PLoS ONE
Publication Year :
2018

Abstract

The current study aimed to investigate the incidence and survival patterns of HNSCCs arising from different anatomic sites, potentially related (the oropharynx) or unrelated (the oral cavity, the larynx/hypopharynx) to HPV, to provide clues on possible growing impact of HPV in the epidemiology of HNSCC in Italy. Epidemiological data were retrieved from ten long-term Cancer Registries covering a population of 7.8 million inhabitants. Trends were described by means of the estimated annual percent change (APC) stratified by age and gender, and compared between HPV-related and HPV-unrelated anatomical sites. The data regarding 28,295 HNSCCs diagnosed in Italy between 1988 and 2012 were analyzed. In males, the incidence rate (IR) of cancers arising from sites unrelated to HPV infection significantly decreased in all age groups (APC:-3.31 for larynx/hypopharynx; APC:-1.77 for oral cavity), whereas stable IR were observed for cancers arising from sites related to HPV infection. In females, IR for cancers from HPV-related sites increased significantly over the observed period; the largest increment was noted in those over 60 (APC:2.92%) who also showed a significantly lower number of HNSCCs from the larynx/hypopharynx (APC:- 0.84) and a significantly higher number of oral cavity tumors (APC = 2.15). The five-year relative survival remained largely unchanged in the patients with laryngeal/hypopharyngeal SCC and, conversely, significantly improved in the patients with SCC at HPV-related sites. The trends observed suggest a potential increasing impact of HPV infection on the epidemiology of HNSCC in Italy, but to a lesser extent and with a different pattern from that observed in other Western countries.

Details

Language :
English
Database :
OpenAIRE
Journal :
PLoS ONE, Vol 13, Iss 2, p e0192621 (2018), PLoS ONE
Accession number :
edsair.doi.dedup.....9f84f0bd5f0e63b4fbbc487743f65f55