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The evolution of the epidemiological landscape of head and neck cancer in Italy: Is there evidence for an increase in the incidence of potentially HPV-related carcinomas?
- Source :
- PLoS ONE, Vol 13, Iss 2, p e0192621 (2018), PLoS ONE
- Publication Year :
- 2018
-
Abstract
- The current study aimed to investigate the incidence and survival patterns of HNSCCs arising from different anatomic sites, potentially related (the oropharynx) or unrelated (the oral cavity, the larynx/hypopharynx) to HPV, to provide clues on possible growing impact of HPV in the epidemiology of HNSCC in Italy. Epidemiological data were retrieved from ten long-term Cancer Registries covering a population of 7.8 million inhabitants. Trends were described by means of the estimated annual percent change (APC) stratified by age and gender, and compared between HPV-related and HPV-unrelated anatomical sites. The data regarding 28,295 HNSCCs diagnosed in Italy between 1988 and 2012 were analyzed. In males, the incidence rate (IR) of cancers arising from sites unrelated to HPV infection significantly decreased in all age groups (APC:-3.31 for larynx/hypopharynx; APC:-1.77 for oral cavity), whereas stable IR were observed for cancers arising from sites related to HPV infection. In females, IR for cancers from HPV-related sites increased significantly over the observed period; the largest increment was noted in those over 60 (APC:2.92%) who also showed a significantly lower number of HNSCCs from the larynx/hypopharynx (APC:- 0.84) and a significantly higher number of oral cavity tumors (APC = 2.15). The five-year relative survival remained largely unchanged in the patients with laryngeal/hypopharyngeal SCC and, conversely, significantly improved in the patients with SCC at HPV-related sites. The trends observed suggest a potential increasing impact of HPV infection on the epidemiology of HNSCC in Italy, but to a lesser extent and with a different pattern from that observed in other Western countries.
- Subjects :
- Male
Oncology
Viral Diseases
lcsh:Medicine
Alphapapillomavirus
Geographical locations
0302 clinical medicine
Animal Cells
Epidemiology of cancer
Medicine and Health Sciences
HPV
papilloma virus
head and neck cancer
Registries
030212 general & internal medicine
lcsh:Science
education.field_of_study
Alcohol Consumption
Multidisciplinary
Relative survival
Incidence
Incidence (epidemiology)
HPV infection
Squamous Cell Carcinomas
Middle Aged
Head and Neck Tumors
Europe
Infectious Diseases
Italy
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
Female
Cellular Types
Research Article
Adult
Human Papillomavirus Infection
medicine.medical_specialty
Immune Cells
Urology
Immunology
Population
Sexually Transmitted Diseases
Antigen-Presenting Cells
Carcinomas
03 medical and health sciences
Head and Neck Squamous Cell Carcinoma
Diagnostic Medicine
Internal medicine
Cancer Detection and Diagnosis
medicine
otorhinolaryngologic diseases
Humans
European Union
education
Nutrition
Aged
Genitourinary Infections
Squamous Cell Carcinoma of Head and Neck
business.industry
Head and neck cancer
lcsh:R
Cancers and Neoplasms
Biology and Life Sciences
Cancer
Cell Biology
medicine.disease
Survival Analysis
Head and neck squamous-cell carcinoma
papilloma viru
Diet
Tumor Virus Infections
stomatognathic diseases
Head and Neck Cancers
Age Groups
People and Places
Population Groupings
lcsh:Q
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- PLoS ONE, Vol 13, Iss 2, p e0192621 (2018), PLoS ONE
- Accession number :
- edsair.doi.dedup.....9f84f0bd5f0e63b4fbbc487743f65f55