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MRI demonstration of gadolinium deposition in bone after monthly triple-dose gadopentetate dimeglumine and correlation with frequency of hypophosphatemia
- Source :
- Clinical imaging. 70
- Publication Year :
- 2020
-
Abstract
- OBJECTIVES We retrospectively analyzed data of the BECOME trial to investigate whether serial administration of triple-dose (3-dose) gadopentetate dimeglumine would result in the development of T1 signal-to-noise (S/N) changes in the cranial diploic space and whether S/N changes correlated with on-study hypophosphatemia. METHODS Signal intensity analysis was performed on the first year's data of the BECOME trial using 3-dose Gd (14 months, maximum number of doses, 39, mean: 36). Routine blood and urine tests were obtained each month for safety monitoring. Linear mixed regression modeling with random intercept was used to analyze monthly signal-to-noise ratio (S/N = Bone/Air) using an ROI of the diploic space created from T2W images and overlaid on T1FS (T1 fat-saturated) images. Incidence of phosphate abnormalities was analyzed using the general estimation equation; correlation of phosphate and S/N change was achieved with type 3 test of fixed effects. RESULTS Cranial diploic space T1FS S/N increased over 14 months: S/N = 0.039 mean monthly increase (S.E. 0.008; p
- Subjects :
- Gadolinium DTPA
Hypophosphatemia
Gadolinium
Mixed regression
chemistry.chemical_element
Contrast Media
Urine
030218 nuclear medicine & medical imaging
Correlation
03 medical and health sciences
0302 clinical medicine
Meglumine
Organometallic Compounds
Medicine
Humans
Radiology, Nuclear Medicine and imaging
Diploic space
Retrospective Studies
business.industry
medicine.disease
Magnetic Resonance Imaging
chemistry
030220 oncology & carcinogenesis
Signal intensity
Nuclear medicine
business
Random intercept
Subjects
Details
- ISSN :
- 18734499
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- Clinical imaging
- Accession number :
- edsair.doi.dedup.....9f8fdabaff69dc1ac41878d2d29de4de