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Advanced donor age does not increase risk of hepatocellular carcinoma recurrence after liver transplantation: a retrospective two-center analysis using competing risk analysis

Authors :
Leonardo Centonze
Romain Lesourd
Caroline Jezequel
Andrea Lauterio
Edouard Bardou-Jacquet
Riccardo De Carlis
Stefano Di Sandro
Luciano De Carlis
C. Cusumano
Fabio Ferla
Michel Rayar
Giovanni Battista Levi Sandri
Christophe Camus
CHU Pontchaillou [Rennes]
Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB)
Ospedale Niguarda
Centre d'Investigation Clinique [Rennes] (CIC)
Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)
Jonchère, Laurent
Cusumano, C
De Carlis, L
Centonze, L
Lesourd, R
Levi Sandri, G
Lauterio, A
De Carlis, R
Ferla, F
Di Sandro, S
Camus, C
Jezequel, C
Bardou-Jacquet, E
Rayar, M
Università degli Studi di Milano-Bicocca [Milano] (UNIMIB)
Université de Rennes 1 (UR1)
Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)
Source :
Transplant International, Transplant International, 2021, 34 (10), pp.1948-1958. ⟨10.1111/tri.13950⟩, Transplant International, Wiley, 2021, 34 (10), pp.1948-1958. ⟨10.1111/tri.13950⟩
Publication Year :
2021
Publisher :
HAL CCSD, 2021.

Abstract

The impact of donor age on the recurrence of hepatocellular carcinoma (HCC) after liver transplantation is still debated. Between 2002 and 2014, all patients transplanted for HCC in 2 European liver transplantation tertiary centres were retrospectively reviewed. Risk factors for HCC recurrence were assessed using competing risk analysis, and the impact of donor age < or ≥65years and < or ≥80years was specifically evaluated after propensity score matching. 728 patients transplanted with a median follow-up of 86months were analysed. The 1-, 3- and 5-year recurrence rates were 4.9%, 10.7% and 13.9%, respectively. In multivariable analysis, recipient age (sHR: 0.96 [0.93; 0.98], P&nbsp

Details

Language :
English
ISSN :
09340874 and 14322277
Database :
OpenAIRE
Journal :
Transplant International, Transplant International, 2021, 34 (10), pp.1948-1958. ⟨10.1111/tri.13950⟩, Transplant International, Wiley, 2021, 34 (10), pp.1948-1958. ⟨10.1111/tri.13950⟩
Accession number :
edsair.doi.dedup.....9f95691d691c345d0d2389a83339051f