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Overexpression of microRNA-24 increases the sensitivity to paclitaxel in drug-resistant breast carcinoma cell lines via targeting ABCB9
- Source :
- Oncology Letters
- Publication Year :
- 2016
- Publisher :
- Spandidos Publications, 2016.
-
Abstract
- Paclitaxel has been widely used in the treatment of breast cancer. However, the development of drug resistance often increases the failure of chemotherapy. Growing evidence has reported the significant role of microRNAs (miRs) in drug resistance. The present study identified that miR-24 was significantly downregulated in paclitaxel-resistant (PR) breast cancer patients and in MCF-7/PR human breast carcinoma cells, and that overexpression of miR-24 could increase the effect of paclitaxel on drug-resistant breast carcinoma cells. Furthermore, miR-24 could directly bind to the 3'-untranslated region of ATP binding cassette B9 to downregulate its expression, thereby reducing drug transportation and improving the anti-tumor effect of paclitaxel on breast cancer cells. In vivo experiments also demonstrated that overexpression of miR-24 could increase the sensitivity of drug-resistant MCF-7 cells to paclitaxel. In conclusion, the present results suggested a novel function for miR-24 in reducing paclitaxel resistance in breast cancer, which may be of important clinical significance.
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
medicine.medical_treatment
miR-24
Drug resistance
Biology
03 medical and health sciences
chemistry.chemical_compound
breast cancer
0302 clinical medicine
Breast cancer
Internal medicine
medicine
Carcinoma
skin and connective tissue diseases
Chemotherapy
Oncogene
Cancer
Articles
medicine.disease
paclitaxel resistance
ABCB9
030104 developmental biology
Paclitaxel
chemistry
030220 oncology & carcinogenesis
Cancer research
Breast carcinoma
Subjects
Details
- ISSN :
- 17921082 and 17921074
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Oncology Letters
- Accession number :
- edsair.doi.dedup.....9fa8b72da9432686b2a2208394ff1f90