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Inhibitory Activity of Pyrroloisoxazolidine Derivatives against Chlamydia trachomatis
- Source :
- BioMed Research International, BioMed Research International, Vol 2021 (2021)
- Publication Year :
- 2021
- Publisher :
- Hindawi Limited, 2021.
-
Abstract
- The obligate intracellular bacterium Chlamydia trachomatis is a group of worldwide human pathogens that can lead to serious reproductive problems. The frequent clinical treatment failure promoted the development of novel antichlamydial agents. Here, we firstly reported a group of pyrroloisoxazolidine-inhibited C. trachomatis in a dose-dependent manner in vitro. Among them, compounds 1 and 2 exhibited the strongest inhibitory activity with IC50 values from 7.25 to 9.73 μM. The compounds disturbed the whole intracellular life cycle of C. trachomatis, mainly targeting the middle reticulate body proliferation stages. Besides, the compounds partially inhibited the chlamydial infection by reducing elementary body infectivity at high concentration. Our findings suggest the potential of pyrroloisoxazolidine derivatives as promising lead molecules for the development of antichlamydial agents.
- Subjects :
- 0301 basic medicine
Article Subject
030106 microbiology
Chlamydia trachomatis
Human pathogen
Inhibitory postsynaptic potential
medicine.disease_cause
General Biochemistry, Genetics and Molecular Biology
Microbiology
03 medical and health sciences
medicine
Humans
Infectivity
General Immunology and Microbiology
biology
Obligate
General Medicine
biology.organism_classification
In vitro
Anti-Bacterial Agents
030104 developmental biology
Lymphogranuloma Venereum
Medicine
Bacteria
Intracellular
Research Article
HeLa Cells
Subjects
Details
- ISSN :
- 23146141 and 23146133
- Volume :
- 2021
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....9fb80d502d6d5e430d84fddff5721a3c