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An experimental study of amniotic lacrimal duct stents in the treatment of perimenopausal female rabbits with dry eye
- Source :
- Molecular Medicine Reports
- Publication Year :
- 2018
- Publisher :
- D.A. Spandidos, 2018.
-
Abstract
- The aim of the present study was to investigate the effects of an amniotic membrane lacrimal stent in the treatment of dry eye syndrome in a perimenopausal rabbit model. In total, 48 healthy female rabbits were randomly divided into four groups (12 rabbits/group): Group A, sham-operated group; group B, negative control group; group C, sham-implantation group; and group D, implantation with amniotic membrane lacrimal stents. A Schirmer I test (SIT), corneal fluorescein staining, optical coherence tomography angiography and corneal confocal microscopy were conducted and the biomechanical properties of the amniotic membrane were measured prior to and 2, 4 and 6 weeks after the operations. There were marked differences in the amount of tear secretion and the SIT following the operation compared with prior to the operation. The amount of tear secretion of group B and C was significantly reduced (F=8.894; P=0.0017). Compared with groups A, B and C, group D demonstrated a significant increase in the amount of tear secretion and a significant reduction in SIT (P0.05). The cornea epithelial of groups A and D was significantly thinner compared with groups B and C. The superior part [superior temporal (ST)5, superior (S)5, superior nasal (SN)5, ST6, S6 and SN6] was significantly thinner compared with the central part of the cornea epithelium. The corneal epithelia of all groups were thin in the center and thick at the edge. At 6 weeks after the operation, group D exhibited a markedly decreased number of anterior stromal luminescent cells, compared with groups A, B and C. Furthermore, the bending degree of corneal stromal neural trunks was significantly improved, and the density, branches and curvature of corneal epithelium sub-basal nerves ameliorated to a certain extent (P
- Subjects :
- 0301 basic medicine
Cancer Research
medicine.medical_specialty
Lacrimal duct
medicine.medical_treatment
perimenopausal female rabbits
Biochemistry
03 medical and health sciences
dry eye
0302 clinical medicine
Cornea
Ophthalmology
Genetics
medicine
Animals
Humans
Tear secretion
Amnion
Fluorescein Angiography
Molecular Biology
amniotic membrane lacrimal stent
Corneal epithelium
medicine.diagnostic_test
business.industry
Therapeutic effect
Epithelium, Corneal
Lacrimal Apparatus
Stent
Articles
Fluorescein angiography
Epithelium
eye diseases
Perimenopause
Disease Models, Animal
030104 developmental biology
medicine.anatomical_structure
Treatment Outcome
Oncology
Tears
030221 ophthalmology & optometry
Molecular Medicine
Dry Eye Syndromes
Female
Stents
sense organs
Rabbits
business
Tomography, Optical Coherence
Subjects
Details
- Language :
- English
- ISSN :
- 17913004 and 17912997
- Volume :
- 19
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Molecular Medicine Reports
- Accession number :
- edsair.doi.dedup.....9fc078239e6c76b1749d5bf321e4e3a4