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Peritumoral Activated Hepatic Stellate Cells Predict Poor Clinical Outcome in Hepatocellular Carcinoma After Curative Resection
- Source :
- American Journal of Clinical Pathology. 131:498-510
- Publication Year :
- 2009
- Publisher :
- Oxford University Press (OUP), 2009.
-
Abstract
- The inflammatory components of the liver remnant after hepatocellular carcinoma (HCC) resection are of prognostic importance. We evaluated prognostic potential of peritumoral activated hepatic stellate cells (HSCs) in 130 HCC cases. The messenger RNA (mRNA) levels of the functional genes in HSCs (ie, seprase, osteonectin, and tenascin-C), quantitated by real-time quantitative polymerase chain reaction, and the density of peritumoral Foxp3+ T-regulatory cells (Tregs) and CD68+ macrophages (MΦ), assessed immunohistochemically in tissue microarray sections, were positively correlated with the density of peritumoral activated HSCs. The density (P = .007 for recurrence-free survival [RFS] and P =.021 for overall survival [OS]) and functional genes (seprase, P = .001 for RFS; osteonectin, P = .007 for RFS and P =.021 for OS) of peritumoral activated HSCs independently contributed to high recurrence or death rates, as did peritumoral Tregs or MΦ. Moreover, peritumoral HSCs were related to more early recurrences. It is important to note that the density of peritumoral activated HSCs, in combination with seprase and osteonectin mRNA or density of Tregs and MΦ, might predict prognoses more effectively.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Carcinoma, Hepatocellular
Gene Expression
Kaplan-Meier Estimate
T-Lymphocytes, Regulatory
Antigens, Neoplasm
Endopeptidases
Biomarkers, Tumor
Hepatic Stellate Cells
Carcinoma
Hepatectomy
Humans
Medicine
Osteonectin
RNA, Messenger
Tissue microarray
biology
Reverse Transcriptase Polymerase Chain Reaction
business.industry
CD68
Macrophages
Liver Neoplasms
Serine Endopeptidases
Membrane Proteins
FOXP3
hemic and immune systems
General Medicine
Middle Aged
Prognosis
medicine.disease
Immunohistochemistry
Treatment Outcome
ROC Curve
Gelatinases
Tissue Array Analysis
Hepatocellular carcinoma
biology.protein
Hepatic stellate cell
Female
business
Liver cancer
Subjects
Details
- ISSN :
- 19437722 and 00029173
- Volume :
- 131
- Database :
- OpenAIRE
- Journal :
- American Journal of Clinical Pathology
- Accession number :
- edsair.doi.dedup.....9fd06748a6dc5bda9dfacb0e02763aba