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Enhanced Pneumocystis carinii activity of new primaquine analogues
- Source :
- Bioorganic & Medicinal Chemistry Letters. 10:2205-2208
- Publication Year :
- 2000
- Publisher :
- Elsevier BV, 2000.
-
Abstract
- New analogues of the venerable antimalarial drug primaquine have been synthesized and bioassayed in vivo against Pneumocystis carinii, a life-threatening infection common among immunosuppressed patients. Two of these new compounds are significantly more active than primaquine itself, and provide new information for future drug design and development in this area.
- Subjects :
- Drug
Antifungal Agents
Primaquine
Opportunistic infection
media_common.quotation_subject
Clinical Biochemistry
Pharmaceutical Science
Pharmacology
Biochemistry
Structure-Activity Relationship
In vivo
Drug Discovery
medicine
Animals
Humans
Molecular Biology
media_common
Dose-Response Relationship, Drug
Molecular Structure
Pneumocystis
Chemistry
Organic Chemistry
medicine.disease
Rats
Pneumocystis Infections
Pneumocystis carinii
Drug Design
Molecular Medicine
Female
medicine.drug
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....9fe3799d5163abaac856214e993de809
- Full Text :
- https://doi.org/10.1016/s0960-894x(00)00436-4