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Sentinel Lymph Node Biopsy in Early Stages of Oral Squamous Cell Carcinoma Using the Receptor-Targeted Radiotracer 99mTc-Tilmanocept
- Source :
- Diagnostics, Vol 11, Iss 1231, p 1231 (2021), Diagnostics; Volume 11; Issue 7; Pages: 1231
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Neck management in patients with early-stage, clinically node-negative oral squamous cell carcinoma (OSCC) remains a matter of discussion. Sentinel lymph node biopsy (SLNB) represents a treatment alternative to avoid elective neck dissection (END) in this cohort and different protocols and tracers exist. Here we present the clinical outcome of SLNB using 99mTc-tilmanocept in a two-day protocol in patients suffering from early-stage OSCC. A total of 13 patients (males: 6; females: 7; mean age: 65.7 years, ranging from 47 to 89 years) were included in this study. Most of the patients suffered from an OSCC of the floor of mouth (n = 6), followed by tongue (n = 5) and upper alveolar crest/hard palate (n = 2). Sentinel lymph nodes (SLNs) were successfully identified in all cases (range: 1–7). The average length of hospital stay was 4.7 days (range: 3–8 days) and mean duration of surgical intervention was 121 min (range: 74–233 min). One patient who suffered from an OSCC of the tongue was sentinel lymph node positive (SLN+). The mean follow-up for all sentinel lymph node negative (SLN-) patients (n = 12) was 20.3 months (range: 10–28 months). No local or nodal recurrences were observed within the observation period. In our patient cohort, SLNB using 99mTc-tilmanocept in a two-day protocol proved to be a reliable and safe staging method for patients suffering from early-stage, clinically node-negative OSCC. These results and their possible superiority to colloid tracers have to be confirmed in a prospective randomized controlled study.
- Subjects :
- medicine.medical_specialty
Medicine (General)
medicine.medical_treatment
Clinical Biochemistry
Sentinel lymph node
law.invention
03 medical and health sciences
0302 clinical medicine
R5-920
Randomized controlled trial
Tongue
law
Biopsy
oral squamous cell carcinoma
sentinel lymph node biopsy
neck dissection
radiotracer
tilmanocept
Medicine
030223 otorhinolaryngology
medicine.diagnostic_test
business.industry
Neck dissection
medicine.anatomical_structure
030220 oncology & carcinogenesis
Cohort
Lymph
Hard palate
Radiology
business
Subjects
Details
- Language :
- English
- ISSN :
- 20754418
- Volume :
- 11
- Issue :
- 1231
- Database :
- OpenAIRE
- Journal :
- Diagnostics
- Accession number :
- edsair.doi.dedup.....a0010816d41a73b107a34bc2a6322d1d