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A clinicopathological cohort study of liver pathology in 301 patients with human immunodeficiency virus/acquired immune deficiency syndrome
- Source :
- Hepatology. 61:1721-1729
- Publication Year :
- 2015
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2015.
-
Abstract
- Liver disease complicates human immunodeficiency virus (HIV)/acquired immune deficiency syndrome; however, liver pathology data are limited, particularly from high HIV prevalence countries. We investigated the spectrum and clinicopathological correlates of liver pathology in a high HIV burden setting. In a single-center study, all HIV/acquired immune deficiency syndrome patients with complete clinical and demographic data who underwent liver biopsy were analyzed and clinicopathologically assessed by hepatologists and one of two experienced liver pathologists. We evaluated 301 patients, with a median age of 34 (interquartile range 29-40) years. Women (n = 143) were younger than men (n = 158), with a median age of 33 (interquartile range 28-37) versus 35 (interquartile range 31-41) years, P = 0.001. The majority, 76.1%, were black African. Median CD4 at time of biopsy was 127 (52-260) cells/mm(3) . Drug-induced liver injury was the predominant finding (42.2%), followed by granulomatous inflammation (29%), steatosis/steatohepatitis (19.3%), hepatitis B (19%), and hepatitis C coinfection (3.3%), with more than one pathology in 16.2%. With granulomatous inflammation, 52% met the criteria for tuberculosis immune reconstitution syndrome. By univariate analysis, cotrimoxazole and antiretroviral therapy conferred risk for drug injury (odds ratio [OR] = 2.78 [1.72-4.48], P 0.001; OR = 1.69 [1.06-2.68], P = 0.027). In multivariate analysis, cotrimoxazole was associated with a cholestatic or ductopenic injury (OR = 7.05 [2.50-19.89], P 0.001; OR = 17.6 [3.26-95.3], P 0.0001); efavirenz was associated with nonspecific hepatitis or submassive necrosis (OR = 4.3 [1.92-9.83], P 0.001; OR = 10.46 [2.7-40.5], P 0.001). Cholestatic injury was associated with female gender and a CD4 of200 cells/mm(3) , and submassive necrosis was associated with younger age. Hepatitis B demonstrated no association.In a high HIV burden area, drug-induced liver injury due to antiretroviral therapy and cotrimoxazole was a frequent clinicopathological finding; Mycobacterium tuberculosis was the leading opportunistic infection, with more than half of patients fulfilling criteria for tuberculosis immune reconstitution syndrome; liver biopsy remains a useful diagnostic procedure in this setting.
- Subjects :
- Adult
Male
medicine.medical_specialty
Anti-HIV Agents
Opportunistic infection
HIV Infections
Gastroenterology
Cohort Studies
Liver disease
Internal medicine
medicine
Humans
Acquired Immunodeficiency Syndrome
Hepatology
medicine.diagnostic_test
business.industry
Liver Diseases
Hepatitis C
Hepatitis B
medicine.disease
Liver biopsy
Immunology
Coinfection
Female
Chemical and Drug Induced Liver Injury
Steatohepatitis
business
Subjects
Details
- ISSN :
- 15273350 and 02709139
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Hepatology
- Accession number :
- edsair.doi.dedup.....a02f2d94eae70805ca34ee8ae6029067