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Metabolism and Immune Modulation in Patients with Solid Tumors: Systematic Review of Preclinical and Clinical Evidence
- Source :
- Cancers, Cancers, Vol 12, Iss 1153, p 1153 (2020)
- Publication Year :
- 2020
-
Abstract
- Several immunotherapy agents are the standard of care of many solid malignancies. Nevertheless, the majority of patients do not benefit from the currently available immunotherapies. It is therefore of paramount importance to identify the prognostic and predictive factors of tumor response/resistance and to design effective therapeutic strategies to overcome primary resistance and improve the efficacy of immunotherapy. The aim of this review is to underline the influence of the tumor and host metabolism on the antitumor immune response and to discuss possible strategies to improve the efficacy of available treatments by targeting the specific metabolic pathways in tumors or immune cells and by modifying patients’ nutritional statuses. A systematic search of the Medline and EMBASE databases was carried out to identify scientific papers published until February 2020, which reported original research articles on the influence of tumor or host metabolism on antitumor immune response. The literature data showed the key role of glycolysis and mitochondrial oxidative phosphorylation, arginine, tryptophan, glutamine, lipid metabolism and microbiome on immune cell function. Moreover, specific nutritional behaviors, such as a low dietary intake of vitamin C, low glycemic index and alpha-linolenic acid, eicosapentenoic acid, docosahexaenoic acid, ornithine ketoglutarate, tryptophan and probiotic supplementation were associated with the potential clinical benefits from the currently available immunotherapies.
- Subjects :
- 0301 basic medicine
Cancer Research
Arginine
medicine.medical_treatment
cancer metabolism
Review
Bioinformatics
lcsh:RC254-282
immune response
03 medical and health sciences
0302 clinical medicine
Immune system
Medicine
Microbiome
Immune response
immune-nutrition
Nutrition
business.industry
Lipid metabolism
Immunotherapy
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Cancer metabolism
Glutamine
Metabolic pathway
030104 developmental biology
nutrition
Oncology
Docosahexaenoic acid
030220 oncology & carcinogenesis
Immune-nutrition
immunotherapy
business
Subjects
Details
- ISSN :
- 20726694
- Volume :
- 12
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Cancers
- Accession number :
- edsair.doi.dedup.....a04071fea7e0e4b533de64d1efa36f8b