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Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells
- Source :
- Nature Communications, Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
- Publication Year :
- 2021
- Publisher :
- Nature Publishing Group UK, 2021.
-
Abstract
- Tissue mononuclear phagocytes (MNP) are specialised in pathogen detection and antigen presentation. As such they deliver HIV to its primary target cells; CD4 T cells. Most MNP HIV transmission studies have focused on epithelial MNPs. However, as mucosal trauma and inflammation are now known to be strongly associated with HIV transmission, here we examine the role of sub-epithelial MNPs which are present in a diverse array of subsets. We show that HIV can penetrate the epithelial surface to interact with sub-epithelial resident MNPs in anogenital explants and define the full array of subsets that are present in the human anogenital and colorectal tissues that HIV may encounter during sexual transmission. In doing so we identify two subsets that preferentially take up HIV, become infected and transmit the virus to CD4 T cells; CD14+CD1c+ monocyte-derived dendritic cells and langerin-expressing conventional dendritic cells 2 (cDC2).<br />Epithelial tissue mononuclear phagocytes (MNP) can transmit HIV to CD4 T cells, but less is known about sub-epithelial cells. Here, the authors describe MNPs in human anogenital and colorectal tissues and find that CD14+CD1c+ monocyte-derived dendritic cells and langerin-expressing conventional dendritic cells 2 preferentially take up and transmit HIV.
- Subjects :
- 0301 basic medicine
CD4-Positive T-Lymphocytes
Sexual transmission
Langerin
Receptors, CCR5
Transcription, Genetic
Sialic Acid Binding Ig-like Lectin 1
Science
CD14
Antigen presentation
Lipopolysaccharide Receptors
General Physics and Astronomy
Anal Canal
Inflammation
HIV Infections
Virus-host interactions
General Biochemistry, Genetics and Molecular Biology
Virus
Article
Monocytes
03 medical and health sciences
0302 clinical medicine
Antigen
Antigens, CD
medicine
Humans
Lectins, C-Type
Collagenases
Genitalia
Receptor
Cell Shape
Phagocytes
Multidisciplinary
Retrovirus
Mucous Membrane
biology
General Chemistry
Dendritic Cells
Dermis
Innate immune cells
030104 developmental biology
Mannose-Binding Lectins
Phenotype
Immunology
biology.protein
HIV-1
medicine.symptom
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.doi.dedup.....a05041045ac97a6f5f9590dae71f6fd0