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Testicular germ-cell tumours and penile squamous cell carcinoma: Appropriate management makes the difference

Testicular germ-cell tumours and penile squamous cell carcinoma: Appropriate management makes the difference

Authors :
Nicola Nicolai
Davide Biasoni
Mario A. Catanzaro
Maurizio Colecchia
Annalisa Trama
Monika Hackl
Elizabeth Van Eycken
Kris Henau
Nadya Dimitrova
Mario Sekerija
Ladislav Dušek
Margit Mägi
Nea Malila
Maarit Leinonen
Michel Velten
Xavier Troussard
Veronique Bouvier
Anne-Valérie Guizard
Anne-Marie Bouvier
Patrick Arveux
Marc Maynadié
Anne-Sophie Woronoff
Michel Robaszkiewic
Isabelle Baldi
Alain Monnereau
Brigitte Tretarre
Marc Colonna
Florence Molinié
Simona Bara
Claire Schvartz
Bénédicte Lapôtre-Ledoux
Pascale Grosclaude
Roland Stabenow
Sabine Luttmann
Alice Nennecke
Jutta Engel
Gabriele Schubert-Fritschle
Jan Heidrich
Bernd Holleczek
Jón Gunnlaugur Jónasson
Kerri Clough-Gorr
Harry Comber
Guido Mazzoleni
Adriano Giacomin
Antonella Sutera Sardo
Alessandr Barchielli
Diego Serraino
Roberta De Angelis
Sandra Mallone
Andrea Tavilla
Daniela Pierannunzio
Silvia Rossi
Mariano Santaquilani
Arnold Knijn
Fabio Pannozzo
Valerio Gennaro
Lucia Benfatto
Paolo Ricci
Mariangela Autelitano
Gianbattista Spagnoli
Mario Fusco
Mario Usala
Francesco Vitale
Maria Michiara
Rosario Tumino
Lucia Mangone
Fabio Falcini
Stefano Ferretti
Rosa Angela Filiberti
Enza Marani
Arturo Iannelli
Flavio Sensi
Silvano Piffer
Maria Gentilini
Anselmo Madeddu
Antonio Ziino
Sergio Maspero
Pina Candela
Fabrizio Stracci
Giovanna Tagliabue
Massimo Rugge
Gemma Gatta
Laura Botta
Riccardo Capocaccia
Santa Pildava
Giedre Smailyte
Neville Calleja
Tom Børge Johannesen
Jadwiga Rachtan
Stanisław Góźdź
Jerzy Błaszczyk
Kamila Kępska
Gonçalo Forjaz de Lacerda
Maria José Bento
Ana Miranda
Chakameh Safaei Diba
Enrique Almar
Nerea Larrañaga
Arantza Lopez de Munain
Ana Torrella-Ramos
José María Díaz García
Rafael Marcos-Gragera
Maria Josè Sanchez
Carmen Navarro
Diego Salmeron
Conchi Moreno-Iribas
Jaume Galceran
Marià Carulla
Mohsen Mousavi
Christine Bouchardy
Silvia M. Ess
Andrea Bordoni
Isabelle Konzelmann
Jem Rashbass
Anna Gavin
David H. Brewster
Dyfed Wyn Huws
Otto Visser
Magdalena Bielska-Lasota
Maja Primic-Zakelj
Ian Kunkler
Ellen Benhamou
Nicolai N.
Biasoni D.
Catanzaro M.A.
Colecchia M.
Trama A.
Hackl M.
Eycken E.V.
Henau K.
Dimitrova N.
Sekerija M.
Dusek L.
Magi M.
Malila N.
Leinonen M.
Velten M.
Troussard X.
Bouvier V.
Guizard A.-V.
Bouvier A.-M.
Arveux P.
Maynadie M.
Woronoff A.-S.
Robaszkiewic M.
Baldi I.
Monnereau A.
Tretarre B.
Colonna M.
Molinie F.
Bara S.
Schvartz C.
Lapotre-Ledoux B.
Grosclaude P.
Stabenow R.
Luttmann S.
Nennecke A.
Engel J.
Schubert-Fritschle G.
Heidrich J.
Holleczek B.
Jonasson J.G.
Clough-Gorr K.
Comber H.
Mazzoleni G.
Giacomin A.
Sutera Sardo A.
Barchielli A.
Serraino D.
De Angelis R.
Mallone S.
Tavilla A.
Pierannunzio D.
Rossi S.
Santaquilani M.
Knijn A.
Pannozzo F.
Gennaro V.
Benfatto L.
Ricci P.
Autelitano M.
Spagnoli G.
Fusco M.
Usala M.
Vitale F.
Michiara M.
Tumino R.
Mangone L.
Falcini F.
Ferretti S.
Filiberti R.A.
Marani E.
Iannelli A.
Sensi F.
Piffer S.
Gentilini M.
Madeddu A.
Ziino A.
Maspero S.
Candela P.
Stracci F.
Tagliabue G.
Rugge M.
Gatta G.
Botta L.
Capocaccia R.
Pildava S.
Smailyte G.
Calleja N.
Johannesen T.B.
Rachtan J.
Gozdz S.
Blaszczyk J.
Kepska K.
de Lacerda G.F.
Bento M.J.
Miranda A.
Diba C.S.
Almar E.
Larranaga N.
de Munain A.L.
Torrella-Ramos A.
Diaz Garcia J.M.
Marcos-Gragera R.
Sanchez M.J.
Navarro C.
Salmeron D.
Moreno-Iribas C.
Galceran J.
Carulla M.
Mousavi M.
Bouchardy C.
M. Ess S.
Bordoni A.
Konzelmann I.
Rashbass J.
Gavin A.
Brewster D.H.
Huws D.W.
Visser O.
Bielska-Lasota M.
Primic-Zakelj M.
Kunkler I.
Benhamou E.
Nicolai, N
Biasoni, D
Catanzaro, Ma
Colecchia, M
Trama, A
Hackl, M
Van Eycken, E
Henau, K
Dimitrova, N
Sekerija, M
Dusek, L
Maagi, M
Malila, N
Leinonen, M
Velten, M
Troussard, X
Bouvier, V
Guizard, Av
Bouvier, Am
Arveux, P
Maynadie, M
Woronoff, A
Robaszkiewicz, M
Baldi, I
Monnereau, A
Tretarre, B
Colonna, M
Molinie, F
Bara, S
Schvartz, C
Lapotre-Ledoux, B
Grosclaude, P
Stabenow, R
Luttmann, S
Nennecke, A
Engel, J
Schubert-Fritschle, G
Heidrich, J
Holleczek, B
Jonasson, Jg
Clough-Gorr, K
Comber, H
Mazzoleni, G
Giacomin, A
Sardo, A
Barchielli, A
Serraino, D
De Angelis, R
Mallone, S
Tavilla, A
Pierannunzio, D
Rossi, S
Santaquilani, M
Knijn, A
Pannozzo, F
Gennaro, V
Benfatto, L
Ricci, P
Autelitano, M
Spagnoli, G
Fusco, M
Usala, M
Vitale, F
Michiara, M
Tumino, R
Mangone, L
Falcini, F
Ferretti, S
Filiberti, Ra
Marani, E
Iannelli, A
Sensi, F
Puffer, S
Gentilini, M
Madeddu, A
Ziino, A
Maspero, S
Candela, P
Stracci, F
Tagliabue, G
Rugge, M
Gatta, G
Botta, L
Capocaccia, R
Pildava, S
Smailyte, G
Calleja, N
Johannesen, Tb
Rachtan, J
Gozdz, S
Blaszczyk, J
Kepska, K
de Lacerda, Gf
Bento, Mj
Miranda, A
Diba, C
Almar, E
Larranaga, N
de Munain, Al
Torrella-Ramos, M
Garcia, Jmd
Marcos-Gragera, R
Sanchez, Mj
Navarro, C
Salmeron, D
Moreno-Iribas, C
Galceran, J
Carulla, M
Mousavi, M
Bouchardy, C
Ess, Sm
Bordoni, A
Konzelmann, I
Rashbass, J
Gavin, A
Brewster, Dh
Huws, Dw
Visser, O
Bielska-Lasota, M
Primic-Zakelj, M
Kunkler, I
Benhamou, E
Publication Year :
2018
Publisher :
W.B. Saunders Ltd, 2018.

Abstract

Germ-cell tumours (GCT) of the testis and penile squamous cell carcinoma (PeSCC) are a rare and a very rare uro-genital cancers, respectively. Both tumours are well defined entities in terms of management, where specific recommendations - in the form of continuously up-to-dated guide lines- are provided. Impact of these tumour is relevant. Testicular GCT affects young, healthy men at the beginning of their adult life. PeSCC affects older men, but a proportion of these patients are young and the personal consequences of the disease may be devastating. Deviation from recommended management may be a reason of a significant prognostic worsening, as proper treatment favourably impacts on these tumours, dramatically on GCT and significantly on PeSCC. RARECAREnet data may permit to analyse how survivals may vary according to geographical areas, histology and age, leading to assume that non-homogeneous health-care resources may impact the cure and definitive outcomes. In support of this hypothesis, some epidemiologic datasets and clinical findings would indicate that survival may improve when appropriate treatments are delivered, linked to a different accessibility to the best health institutions, as a consequence of geographical, cultural and economic barriers. Finally, strong clues based on epidemiological and clinical data support the hypothesis that treatment delivered at reference centres or under the aegis of a qualified multi-institutional network is associated with a better prognosis of patients with these malignancies. The ERN EURACAN represents the best current European effort to answer this clinical need.

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....a07692e1eb572acf6de27613f8111637