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Filariasis Testing in a Jird Model: New Drug Leads from Some Old Standbys
- Source :
- The American Journal of Tropical Medicine and Hygiene. 51:791-796
- Publication Year :
- 1994
- Publisher :
- American Society of Tropical Medicine and Hygiene, 1994.
-
Abstract
- A total of 65 compounds, most of which were from chemical classes having members known to be active against one or more parasitic organisms, were evaluated against Brugia pahangi and Acanthocheilonema viteae for macrofilaricidal activity in male Mongolian jirds (Meriones unguiculatus). Sixteen of the 65 compounds tested suppressed the number of parasites. Of these 16, three were suppressive for B. pahangi, 10 for A. viteae, and three for both parasites. The antibiotic nigericin and the antihistaminic isothipendyl were found to be most active.
- Subjects :
- Male
Drug
Brugia pahangi
Nigericin
medicine.drug_class
media_common.quotation_subject
Antibiotics
Helminthiasis
Dipetalonema
Filariasis
Microbiology
chemistry.chemical_compound
Dipetalonema Infections
Virology
medicine
Animals
media_common
Acanthocheilonema viteae
biology
biology.organism_classification
medicine.disease
Disease Models, Animal
Filaricides
Infectious Diseases
chemistry
Immunology
Female
Parasitology
Gerbillinae
Subjects
Details
- ISSN :
- 14761645 and 00029637
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- The American Journal of Tropical Medicine and Hygiene
- Accession number :
- edsair.doi.dedup.....a077b592ccdc048042175363eaad4752