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Cadmium oral bioavailability is affected by calcium and phytate contents in food: Evidence from leafy vegetables in mice

Authors :
Albert L. Juhasz
Xiao-San Luo
Gang Li
Rong-Yue Xue
Meng-Ya Li
Jia-Hui Liang
Ning Wang
Han Ning
Meng-Yu Wang
Lena Q. Ma
Hong-Bo Li
Wang, Meng Yu
Li, Meng Ya
Ning, Han
Xue, Rong Yue
Liang, Jia Hui
Wang, Ning
Luo, Xiao San
Li, Gang
Juhasz, Albert L
Ma, Lena Q
Li, Hong Bo
Source :
Journal of Hazardous Materials. 424:127373
Publication Year :
2022
Publisher :
Elsevier BV, 2022.

Abstract

To test high cadmium (Cd) concentration may not be high in health risk when considering Cd bioavailability, we assessed variation of Cd relative bioavailability (RBA, relative to CdCl2) using a mouse assay for 14 vegetables of water spinach, amaranth, and pakchoi. Cadmium concentration varied from 0.13 ± 0.01–0.37 ± 0.00 μg g–1 fw. Cadmium-RBA also varied significantly from 22.9 ± 2.12–77.2 ± 4.46%, however, the variation was overall opposite to that of Cd concentration, as indicated by a strong negative correlation between Cd-RBA and Cd concentration (R2 = 0.43). Based on both Cd concentration and bioavailability, the identified high-Cd pakchoi variety resulted in significantly lower Cd intake than the high-Cd varieties of water spinach and amaranth (4.74 ± 0.05 vs. 10.1 ± 0.54 and 8.03 ± 0.04 μg kg–1 bw week–1) due to significantly lower Cd-RBA (22.9 ± 2.12 vs. 77.2 ± 4.46 and 51.3 ± 2.93%). The lower Cd-RBA in pakchoi was due to its significantly higher Ca and lower phytate concentrations, which facilitated the role of Ca in inhibiting intestinal Cd absorption. This was ascertained by observation of decreased Cd-RBA (90.5 ± 12.0% to 63.5 ± 5.53%) for a water spinach when elevating its Ca concentration by 30% with foliar Ca application. Our results suggest that to assess food Cd risk, both total Cd and Cd bioavailability should be considered. Refereed/Peer-reviewed

Details

ISSN :
03043894
Volume :
424
Database :
OpenAIRE
Journal :
Journal of Hazardous Materials
Accession number :
edsair.doi.dedup.....a07cd9da229ff7f5f7dc89e8eb65bcaa