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Skin Autofluorescence and Glycemic Variability
- Source :
- Diabetes technology & therapeutics, 12(7), 581-585. MARY ANN LIEBERT, INC
- Publication Year :
- 2010
- Publisher :
- MARY ANN LIEBERT, INC, 2010.
-
Abstract
- Background: Accumulation of advanced glycation end products (AGEs) is accelerated during glycemic and oxidative stress and is an important predictor of complications in diabetes mellitus (DM).Study Design: Here we both review and present original data on the relationship between skin autofluorescence (SAF), a noninvasive measure of AGEs, and short-and intermediate-term glycemic variations.Results: Acute changes in glucose levels during an oral glucose tolerance test in 56 persons with varying degrees of glucose tolerance did not influence SAF. AGE-rich meals result in a transient postprandial rise in SAF of 10% 2-4 h later. This could not be attributed to meal-induced glycemic changes and is probably caused by the AGE content of the meal. In type 1DM major intermediate-term improvements of glycemic control as depicted by multiple hemoglobin A1c (HbA1c) measurements were associated with lower skin AGE levels. In a well-controlled, stable type 2DM cohort, only a weak correlation was found between SAF and HbA1c. In both studies skin AGE/SAF levels predicted complications of diabetes with an accuracy superior to that of HbA1c. SAF has also been proposed as a new tool in diagnosing impaired glucose tolerance (IGT) and DM. It proved to be more sensitive than either fasting glucose or HbA1c.Conclusions: SAF is not influenced by short-term glycemic variations. AGE-rich meals may, however, cause a transient rise postprandially. There is a weak correlation between SAF or skin AGEs and current or time-integrated HbA1c levels. SAF has strong added value in risk prediction of complications of diabetes and is a promising tool for early detection of diabetes and IGT.
- Subjects :
- Glycation End Products, Advanced
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.disease_cause
Fluorescence
GLUCOSE
Endocrinology
Glycation
Internal medicine
Diabetes mellitus
medicine
Humans
Skin
Glycemic
ACCUMULATION
Glycated Hemoglobin
RISK
Meal
COMPLICATIONS
business.industry
MORTALITY
fungi
DIABETES-MELLITUS
Middle Aged
medicine.disease
Medical Laboratory Technology
Diabetes Mellitus, Type 1
Postprandial
Diabetes Mellitus, Type 2
Cohort
Female
Hemoglobin
business
GLYCATION END-PRODUCTS
FOLLOW-UP
Oxidative stress
Subjects
Details
- Language :
- English
- ISSN :
- 15209156
- Volume :
- 12
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Diabetes technology & therapeutics
- Accession number :
- edsair.doi.dedup.....a07f24a387c040440cb7138dfbd7dd5d