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Antibody production, design and use for biosensor-based applications
- Source :
- Seminars in Cell & Developmental Biology. 20:10-26
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- Currently, the reliable detection and quantification of a multitude of different analytes is crucial in many applications and settings. Biosensors have revolutionised diagnostics for use in point-of-care testing (POC), the detection of food and environmental contaminants, biological warfare agents, illicit drugs and human/animal disease markers. Antibodies continue to play a pivotal role in many sensor devices due to their exquisite specificity for their cognate antigens. In this review current biosensor platforms employing antibodies for molecular recognition are briefly described. The use of molecular biological techniques for the generation and improvement of antibodies is critically examined. Such recombinant antibodies possess improved attributes for use in biosensor development in terms of design, stability, affinity and specificity.
- Subjects :
- Databases, Factual
Animal disease
Biosensing Techniques
Electrochemical Techniques
Cell Biology
Computational biology
Biology
Molecular biology
Antibodies
Recombinant Proteins
Antibody production
Recombinant antibodies
Molecular recognition
Biological warfare
Ribosome display
Animals
Humans
Biosensor
Developmental Biology
Subjects
Details
- ISSN :
- 10849521
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Seminars in Cell & Developmental Biology
- Accession number :
- edsair.doi.dedup.....a0808ac0dc79c1e9704a789e61d3bb00