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Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function
- Source :
- Nature Medicine. 14:125-133
- Publication Year :
- 2008
- Publisher :
- Springer Science and Business Media LLC, 2008.
-
Abstract
- Treacher Collins syndrome (TCS) is a congenital disorder of craniofacial development arising from mutations in TCOF1, which encodes the nucleolar phosphoprotein Treacle. Haploinsufficiency of Tcof1 perturbs mature ribosome biogenesis, resulting in stabilization of p53 and the cyclin G1-mediated cell-cycle arrest that underpins the specificity of neuroepithelial apoptosis and neural crest cell hypoplasia characteristic of TCS. Here we show that inhibition of p53 prevents cyclin G1-driven apoptotic elimination of neural crest cells while rescuing the craniofacial abnormalities associated with mutations in Tcof1 and extending life span. These improvements, however, occur independently of the effects on ribosome biogenesis; thus suggesting that it is p53-dependent neuroepithelial apoptosis that is the primary mechanism underlying the pathogenesis of TCS. Our work further implies that neuroepithelial and neural crest cells are particularly sensitive to cellular stress during embryogenesis and that suppression of p53 function provides an attractive avenue for possible clinical prevention of TCS craniofacial birth defects and possibly those of other neurocristopathies.
- Subjects :
- Male
Transcriptional Activation
Cyclin G1
Ribosomopathy
Neuroepithelial Cells
Apoptosis
Biology
Bone and Bones
Article
General Biochemistry, Genetics and Molecular Biology
Cyclin G
Mice
Cyclins
medicine
Animals
Humans
Body Patterning
Genetics
Neurocristopathy
Cell Cycle
Intracellular Signaling Peptides and Proteins
Nuclear Proteins
Neural crest
General Medicine
Embryo, Mammalian
Phosphoproteins
medicine.disease
Cell biology
Mice, Inbred C57BL
Neuroepithelial cell
Transplantation
Neural Crest
Treacle
Female
Tumor Suppressor Protein p53
Haploinsufficiency
Chickens
Ribosomes
Treacher Collins syndrome
Mandibulofacial Dysostosis
Subjects
Details
- ISSN :
- 1546170X and 10788956
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Nature Medicine
- Accession number :
- edsair.doi.dedup.....a087f50a8f1588b6e15ecefc76c259b9