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Protective and Healing Effects of Ghrelin and Risk of Cancer in the Digestive System
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 22, Iss 10571, p 10571 (2021)
- Publication Year :
- 2021
-
Abstract
- Ghrelin is an endogenous ligand for the ghrelin receptor, previously known as the growth hormone secretagogue receptor. This hormone is mainly produced by endocrine cells present in the gastric mucosa. The ghrelin-producing cells are also present in other organs of the body, mainly in the digestive system, but in much smaller amount. Ghrelin exhibits a broad spectrum of physiological effects, such as stimulation of growth hormone secretion, gastric secretion, gastrointestinal motility, and food intake, as well as regulation of glucose homeostasis and bone formation, and inhibition of inflammatory processes. This review summarizes the recent findings concerning animal and human data showing protective and therapeutic effects of ghrelin in the gut, and also presents the role of growth hormone and insulin-like growth factor-1 in these effects. In addition, the current data on the possible influence of ghrelin on the carcinogenesis, its importance in predicting the risk of developing gastrointestinal malignances, as well as the potential usefulness of ghrelin in the treatment of cancer, have been presented.
- Subjects :
- medicine.medical_specialty
QH301-705.5
Growth hormone secretagogue receptor
Enteroendocrine cell
Review
Protective Agents
cachexia
Catalysis
Inorganic Chemistry
anti-inflammatory effects
Risk Factors
Internal medicine
Neoplasms
Gastric mucosa
Medicine
Glucose homeostasis
Animals
Humans
Biology (General)
Physical and Theoretical Chemistry
Insulin-Like Growth Factor I
Receptor
QD1-999
Molecular Biology
Spectroscopy
business.industry
Organic Chemistry
digestive, oral, and skin physiology
General Medicine
risk of cancer
pretreatment
protection
healing
Growth hormone secretion
Ghrelin
Computer Science Applications
Chemistry
medicine.anatomical_structure
Endocrinology
Glucose
Gastric Mucosa
business
Gastrointestinal Motility
hormones, hormone substitutes, and hormone antagonists
Hormone
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 22
- Issue :
- 19
- Database :
- OpenAIRE
- Journal :
- International journal of molecular sciences
- Accession number :
- edsair.doi.dedup.....a0ae4b86f65ef991663719b229dd9b31