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Combinations of Cytochrome P450 Gene Polymorphisms Enhancing the Risk for Sporadic Colorectal Cancer Related to Red Meat Consumption
- Source :
- Cancer Epidemiology, Biomarkers and Prevention, Cancer Epidemiology, Biomarkers and Prevention, American Association for Cancer Research, 2007, 16 (7), pp.1460-7. ⟨10.1158/1055-9965.EPI-07-0236⟩
- Publication Year :
- 2007
- Publisher :
- American Association for Cancer Research (AACR), 2007.
-
Abstract
- Susceptibility to sporadic colorectal cancers (CRC) is generally thought to be the sum of complex interactions between environmental and genetic factors, all of which contribute independently, producing only a modest effect on the whole phenomenon. However, to date, most research has concealed the notion of interaction and merely focused on dissociate analyses of risk factors to highlight associations with CRC. By contrast, we have chosen a combinative approach here to explore the joint effects of several factors at a time. Through an association study based on 1,023 cases and 1,121 controls, we examined the influence on CRC risk of environmental factors coanalyzed with combinations of six single nucleotide polymorphisms located in cytochrome P450 genes (c.−163A>C and c.1548T>C in CYP1A2, g.−1293G>C and g.−1053C>T in CYP2E1, c.1294C>G in CYP1B1, and c.430C>T in CYP2C9). Whereas separate analyses of the SNPs showed no effect on CRC risk, three allelic variant combinations were found to be associated with a significant increase in CRC risk in interaction with an excessive red meat consumption, thereby exacerbating the intrinsic procarcinogenic effect of this dietary factor. One of these three predisposing combinations was also shown to interact positively with obesity. Provided that they are validated, our results suggest the need to develop robust combinative methods to improve genetic investigations into the susceptibility to CRC. (Cancer Epidemiol Biomarkers Prev 2007;16(7):1460–7)
- Subjects :
- Male
Pathology
Epidemiology
MESH: Aryl Hydrocarbon Hydroxylases
Cohort Studies
MESH: Genotype
MESH: Aged, 80 and over
0302 clinical medicine
Cytochrome P-450 Enzyme System
Risk Factors
MESH: Risk Factors
Genotype
Medicine
MESH: Cohort Studies
Aged, 80 and over
MESH: Aged
MESH: Meat
Genetics
0303 health sciences
MESH: Middle Aged
MESH: Polymorphism, Single Nucleotide
MESH: Genetic Predisposition to Disease
Cytochrome P-450 CYP2E1
Middle Aged
MESH: Case-Control Studies
[SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]
3. Good health
MESH: Cytochrome P-450 CYP1A2
Oncology
Red Meat Consumption
030220 oncology & carcinogenesis
Cytochrome P-450 CYP1B1
MESH: Cytochrome P-450 Enzyme System
Red meat
Female
Aryl Hydrocarbon Hydroxylases
France
Colorectal Neoplasms
Adult
medicine.medical_specialty
Meat
CYP1B1
Single-nucleotide polymorphism
Polymorphism, Single Nucleotide
03 medical and health sciences
MESH: Diet
Cytochrome P-450 CYP1A2
Humans
Genetic Predisposition to Disease
Genetic variability
Allele
Alleles
Aged
Cytochrome P-450 CYP2C9
030304 developmental biology
MESH: Humans
business.industry
MESH: Alleles
Case-control study
MESH: Adult
MESH: Male
Diet
MESH: France
MESH: Cytochrome P-450 CYP2E1
Case-Control Studies
[INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM]
business
MESH: Female
MESH: Colorectal Neoplasms
Subjects
Details
- ISSN :
- 15387755 and 10559965
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Cancer Epidemiology, Biomarkers & Prevention
- Accession number :
- edsair.doi.dedup.....a0bc16b9e1ee1311366e611608497cca