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Alteration of normal level of serum urate may contribute to decrease in estimated glomerular filtration rate decline in healthy Japanese men
- Source :
- Renal Failure, Vol 43, Iss 1, Pp 1408-1415 (2021), Renal Failure, article-version (VoR) Version of Record
- Publication Year :
- 2021
- Publisher :
- Taylor & Francis, 2021.
-
Abstract
- Serum uric acid (SUA) levels have a linear relationship with the estimated glomerular filtration rate (eGFR). It is unclear whether further changes, subsequent to normal level of SUA can attenuate eGFR decline in a healthy population, so we aimed to determine the normal level of SUA that can contribute to preventing kidney dysfunction. In this retrospective cohort study from Japan, annual health checkup data from 2009 to 2014 was collected. After propensity score matching (1:1), data from 2,634 individuals with basal SUA ≤7.0 mg/dL (normal; mean age, 39 y; mean eGFR, 80.8 mL/min/1.73 m2) and 1,642 individuals with basal SUA >7.0 mg/dL (elevated; mean age, 42 y; mean eGFR, 75.0 mL/min/1.73 m2) were collected to determine the relationship between followed-up SUA level and the rate of change in eGFR. In individuals with normal level SUA at baseline, the elevation of SUA (>7.0 mg/dL) accelerated eGFR decline compared to those with normal SUA levels at 5-year follow-up (−4.1 ± 9.6% vs −9.9 ± 9.0%, p < .0001). Digression of SUA level (≤7.0 mg/dL) reduced eGFR decline compared with persistent SUA level over 7.0 mg/dL (−1.5 ± 11.5% vs −7.0 ± 10.1, p < .0001). In multiple linear regression analysis, there was strong association between the rate of change in SUA and eGFR in individuals with basal SUA ≤7.0 and >7.0 mg/dL (standardized coefficient; −0.3348, p < .001 and −.2523, p < .001, respectively). Subsequent to normal level of SUA (under 7.0 mg/dL) may contribute to a decrease in eGFR decline in apparently healthy men.
- Subjects :
- Adult
Male
medicine.medical_specialty
Renal function
hyperuricemia
Kidney
urologic and male genital diseases
Critical Care and Intensive Care Medicine
Japan
Risk Factors
Internal medicine
Humans
Medicine
Hyperuricemia
Renal Insufficiency, Chronic
propensity score
Retrospective Studies
business.industry
Serum uric acid
food and beverages
Normal level
General Medicine
medicine.disease
Diseases of the genitourinary system. Urology
Uric Acid
Serum urate
Linear relationship
Endocrinology
Nephrology
occupational health
Linear Models
Clinical Study
RC870-923
sense organs
business
chronic kidney disease
Glomerular Filtration Rate
Research Article
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Renal Failure, Vol 43, Iss 1, Pp 1408-1415 (2021), Renal Failure, article-version (VoR) Version of Record
- Accession number :
- edsair.doi.dedup.....a0df5aa019507e6955a639ba9fae86a0
- Full Text :
- https://doi.org/10.6084/m9.figshare.16783059.v1