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C-Reactive Protein Predicts Incidence of Dementia in an Elderly Asian Community Cohort
- Source :
- Journal of the American Medical Directors Association. 18:277.e7-277.e11
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Background Many studies have investigated the association between markers for peripheral inflammation and risk of dementia, but the results have been conflicting. We aimed to evaluate the association between a specific inflammation marker, C-reactive protein (CRP), and dementia in an elderly Asian community cohort. Methods The cohort included 1436 individuals (ages 65 and older) from a national representative sample in Taiwan. Dementia incidence was identified using International Classification of Diseases , Ninth Revision codes for vascular dementia, Alzheimer disease, and nonvascular dementia. Baseline characteristics and CRP levels were determined. A Cox proportional hazard model and Fine and Grays model were adjusted for stroke and competing risk of death to estimate the association between inflammation and development of dementia. Results During 11.04 years (median) of follow-up, 607 individuals (50.77%) died and 260 individuals (18.11%) were diagnosed with dementia. Those with high CRP had a 55% higher risk of dementia (hazard ratio 1.55; 95% confidence interval 1.21–2.00) compared with those with normal CRP. After adjusting for possible confounding cardiovascular risk factors, high CRP was independently associated with vascular dementia but not Alzheimer disease. Conclusions In this prospective study of an elderly Asian community cohort with more than 10 years of follow-up, the baseline serum CRP level was associated with future development of vascular dementia, but not Alzheimer disease after adjusting for common cardiovascular risk factors, stroke, and competing risk of death.
- Subjects :
- Male
medicine.medical_specialty
Taiwan
03 medical and health sciences
0302 clinical medicine
Asian People
Predictive Value of Tests
Internal medicine
mental disorders
medicine
Humans
Dementia
Prospective Studies
030212 general & internal medicine
Vascular dementia
Prospective cohort study
Stroke
General Nursing
Aged
Proportional hazards model
business.industry
Incidence
Health Policy
Hazard ratio
General Medicine
medicine.disease
C-Reactive Protein
Cohort
Physical therapy
Female
Geriatrics and Gerontology
Alzheimer's disease
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15258610
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Journal of the American Medical Directors Association
- Accession number :
- edsair.doi.dedup.....a0e5319dfa30536ef445f978f78b5171