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Assembly behaviors of calixarene-based amphiphile and supra-amphiphile and the applications in drug delivery and protein recognition
- Source :
- Advances in Colloid and Interface Science. 269:187-202
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Calixarene is the third generation of supra-molecular compounds after crown ether and cyclodextrin. Amphiphilic calixarene can be obtained by modulation with both hydrophilic group and hydrophobic alkyl chain. Compared with conventional surfactant, amphiphilic calixarene has much lower critical micelle concentration and is much easier to self-assemble into different morphological aggregates. Calixarene-basedsupra-amphiphile can be designed via noncovalent bonds due to the capability of calixarene to recognize surfactant; the binding of a surfactant with calixarene can decrease the critical micelle concentration of surfactant by several times. The calixarene-surfactant complex can self-aggregate to form spherical micelles, vesicles, and spherical nanoparticles, and the aggregation behavior can be controlled by the structures and the molar ratio of surfactant to calixarene and environmental factors. Calixarene-based amphiphile and supra-amphiphile show low cytotoxicity. They can load drugs and assemble into nanocapsules with drugs. The structure of the calixarene-drug complex can respond to external stimuli, rendering the sustained release of the drug and suggesting its potential application as a drug delivery system. Recently, calixarene has also been found to selectively bind proteins, suggesting its prospect in disease diagnosis and intervention treatment in clinics. This review elaborates on the research progress in the self-assembly behaviors of calixarene-based amphiphile and supra-amphiphile and the applications of the calixarenes in drug delivery and protein recognition. The prospectives for the studies are also provided in this review.
- Subjects :
- 02 engineering and technology
010402 general chemistry
01 natural sciences
Micelle
Nanocapsules
Surface-Active Agents
Drug Delivery Systems
Colloid and Surface Chemistry
Pulmonary surfactant
Calixarene
Amphiphile
Animals
Humans
Physical and Theoretical Chemistry
Drug Carriers
Chemistry
Proteins
food and beverages
Surfaces and Interfaces
021001 nanoscience & nanotechnology
Combinatorial chemistry
0104 chemical sciences
Critical micelle concentration
Drug delivery
Calixarenes
0210 nano-technology
Drug carrier
Hydrophobic and Hydrophilic Interactions
Subjects
Details
- ISSN :
- 00018686
- Volume :
- 269
- Database :
- OpenAIRE
- Journal :
- Advances in Colloid and Interface Science
- Accession number :
- edsair.doi.dedup.....a0e60d6d410b6f08f6d3cc2839307e6d