BSA coated gold nanoparticles exhibit size dependent interaction with lung cancer (A549) cells

Background Due to high surface to volume ratio and other unique properties, nanomaterials interact within living system (cells, tissues, organisms) significantly different. Therefore, developing a rational basis for investigation and understanding about how these nanomaterials interact with living system is still a fundamental challenge. Further, it has been well documented that nanomaterials get coated by the proteins present in their surrounding thus constructing a “protein corona”. This event also plays a major role in determining the interaction of nanomaterials with cells/tissues. Therefore, to probe this we have chosen BSA coated gold nanoparticles (AuNPs) as a model system to study the interaction with a mammalian lung cell culture model system.