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Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats
- Source :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP, eLife, Vol 10 (2021)
- Publication Year :
- 2021
-
Abstract
- Escape from threats has paramount importance for survival. However, it is unknown if a single circuit controls escape vigor from innate and conditioned threats. Cholecystokinin (cck)-expressing cells in the hypothalamic dorsal premammillary nucleus (PMd) are necessary for initiating escape from innate threats via a projection to the dorsolateral periaqueductal gray (dlPAG). We now show that in mice PMd-cck cells are activated during escape, but not other defensive behaviors. PMd-cck ensemble activity can also predict future escape. Furthermore, PMd inhibition decreases escape speed from both innate and conditioned threats. Inhibition of the PMd-cck projection to the dlPAG also decreased escape speed. Intriguingly, PMd-cck and dlPAG activity in mice showed higher mutual information during exposure to innate and conditioned threats. In parallel, human functional magnetic resonance imaging data show that a posterior hypothalamic-to-dlPAG pathway increased activity during exposure to aversive images, indicating that a similar pathway may possibly have a related role in humans. Our data identify the PMd-dlPAG circuit as a central node, controlling escape vigor elicited by both innate and conditioned threats.
- Subjects :
- Male
Time Factors
predator
Hypothalamus, Posterior
Video Recording
panic
Central node
Escape Reaction
Conditioning, Psychological
Neural Pathways
Periaqueductal Gray
Biology (General)
Cholecystokinin
Brain Mapping
medicine.diagnostic_test
Behavior, Animal
dorsal premammillary nucleus
General Neuroscience
General Medicine
Fear
Magnetic Resonance Imaging
Visual Perception
Medicine
Female
Dorsum
Adult
QH301-705.5
Science
Mice, Transgenic
Biology
Periaqueductal gray
General Biochemistry, Genetics and Molecular Biology
Young Adult
medicine
Animals
Humans
Rats, Long-Evans
General Immunology and Microbiology
HIPOTÁLAMO
Escape velocity
Mice, Inbred C57BL
Optogenetics
Dorsal premammillary nucleus
escape
Functional magnetic resonance imaging
Neuroscience
Photic Stimulation
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP, eLife, Vol 10 (2021)
- Accession number :
- edsair.doi.dedup.....a0f36eafab31e55df7626bcb54130895