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Altered cardiac reserve is a determinant of exercise intolerance in sickle cell anaemia patients
- Source :
- European Journal of Clinical Investigation. 52
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- BACKGROUND The underlying mechanisms of exercise intolerance in sickle cell anaemia (SCA) patients are complex and not yet completely understood. While latent heart failure at rest could be unmasked upon exercise, most previous studies assessed cardiac function at rest. We aimed to investigate exercise cardiovascular reserve as a potential contributor to exercise intolerance in adult SCA patients. METHODS In this observational prospective study, we compared prospectively 60 SCA patients (median age 31 years, 60% women) to 20 matched controls. All subjects underwent symptom-limited combined exercise echocardiography and oxygen uptake (VO2 ) measurements. Differences between arterial and venous oxygen content (C(a-v)O2 ) were calculated. Cardiac reserve was defined as the absolute change in cardiac index (Ci) from baseline to peak exercise. RESULTS Compared to controls, SCA patients demonstrated severe exercise intolerance (median peakVO2 , 34.3 vs. 19.7 ml/min/kg, respectively, p
- Subjects :
- Adult
Male
Cardiac function curve
medicine.medical_specialty
Clinical Biochemistry
Cardiac index
Anemia, Sickle Cell
Exercise intolerance
Biochemistry
Ventricular Dysfunction, Left
Young Adult
Internal medicine
medicine
Humans
Prospective Studies
Prospective cohort study
Exercise Tolerance
business.industry
Cardiac reserve
Heart
General Medicine
medicine.disease
Sickle cell anemia
Heart failure
Cohort
Cardiology
Female
medicine.symptom
business
Subjects
Details
- ISSN :
- 13652362 and 00142972
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- European Journal of Clinical Investigation
- Accession number :
- edsair.doi.dedup.....a0fe2f6465ae0aba89a839151cc17e40