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The Role of Early Programming and Early Nutrition on the Development and Progression of Celiac Disease: A Review
- Source :
- Nutrients, Digibug. Repositorio Institucional de la Universidad de Granada, instname, Nutrients, Vol 12, Iss 3427, p 3427 (2020), Digibug: Repositorio Institucional de la Universidad de Granada, Universidad de Granada (UGR)
- Publication Year :
- 2020
-
Abstract
- Experimental and epidemiological evidence has shown that modifications of the intrauterine environment can have deleterious consequences for individuals, expressed as an increased risk of su ering non-communicable pathologies in adult life, which is known as the hypothesis of the early origin of diseases or fetal programming. On the other hand, changes in gene expression patterns through epigenetic modifications can be the basis for long-term maintenance of the e ects of fetal programming. In this sense, epigenetics comprises the study of intrauterine disturbances, which develop diseases in the adult, including celiac disease (CD). In addition, early feeding practices could influence the risk of CD development, such as breastfeeding timing and duration and age of gluten introduction in the diet. Gluten acts as a trigger for CD in genetically predisposed subjects, although approximately 30% of the world population has HLA DQ2 or DQ8, the prevalence of the disease is only 1–3%. It is not known what factors act to modify the risk of disease in genetically at-risk subjects. Taking into account all these considerations, the aim of the current review is to elucidate the role of early programming and the e ect of early nutrition on the development and progression of CD. It is logical that attention has been paid to gluten as a key element in preventing the disease. However, there is no strong evidence in favor of the protective factor of breastfeeding, timing of introduction of gluten during lactation, and the development of CD. Diet, genetic risk, microbiota, and environmental interaction are possible triggers of the change in tolerance to an immune response to gluten, but large-scale cohort studies are needed. Emerging scientific concepts, such as epigenetics, may help us establish the role of these factors.<br />University of Granada
- Subjects :
- medicine.medical_specialty
Glutens
Breastfeeding
Protective factor
lcsh:TX341-641
Disease
Review
Bioinformatics
03 medical and health sciences
0302 clinical medicine
030225 pediatrics
Epidemiology
Medicine
biochemistry
Humans
Nutritional Physiological Phenomena
Epigenetics
early programming
chemistry.chemical_classification
Nutrition and Dietetics
business.industry
HLA-DQ2
perinatal nutrition
Gluten
Gastrointestinal Microbiome
Celiac Disease
Breast Feeding
chemistry
Disease Progression
030211 gastroenterology & hepatology
business
lcsh:Nutrition. Foods and food supply
Food Science
Cohort study
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Nutrients, Digibug. Repositorio Institucional de la Universidad de Granada, instname, Nutrients, Vol 12, Iss 3427, p 3427 (2020), Digibug: Repositorio Institucional de la Universidad de Granada, Universidad de Granada (UGR)
- Accession number :
- edsair.doi.dedup.....a10a27363c2e6a02601786df481e087b