Back to Search
Start Over
Development and in vitro evaluation of thiolated chitosan--Poly(methacrylic acid) nanoparticles as a local mucoadhesive delivery system
- Source :
- International journal of biological macromolecules. 48(3)
- Publication Year :
- 2010
-
Abstract
- The main objective of this study was to develop a local, oral mucoadhesive metronidazole benzoate (MET) delivery system that can be applied and removed by the patient for the treatment of periodontal diseases. The results of present study revealed that the retention time of MET at its absorption site could be increased by formulating it into nanoparticles using thiolated chitosan (TCS)–poly(methacrylic acid) (PMAA). The nanoparticles of MET prepared from TCS–PMAA may represent a useful approach for targeting its release at its site of absorption, sustaining its release and improving its oral availability.
- Subjects :
- Poly(methacrylic acid)
Differential Thermal Analysis
Metronidazole Benzoate
Nanoparticle
Absorption (skin)
Biochemistry
Chitosan
chemistry.chemical_compound
Drug Delivery Systems
Polymethacrylic Acids
Structural Biology
Metronidazole
Humans
Molecular Biology
fungi
Mouth Mucosa
Adhesiveness
General Medicine
In vitro
Methacrylic acid
chemistry
Nanoparticles
Delivery system
Nuclear chemistry
Subjects
Details
- ISSN :
- 18790003
- Volume :
- 48
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- International journal of biological macromolecules
- Accession number :
- edsair.doi.dedup.....a11c412d012cad596c8a0d22db10a9d1