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Activation of hedgehog signaling and its association with cisplatin resistance in ovarian epithelial tumors
- Source :
- Oncology Letters
- Publication Year :
- 2018
- Publisher :
- D.A. Spandidos, 2018.
-
Abstract
- Few studies have evaluated Hedgehog (Hh) signaling pathway activation in different types of ovarian tumors including benign, borderline and malignant ovarian tumors. The present study investigated the expression of Hh signaling pathway components (SHH, SMO, PTCH, and GLI1) in 193 ovarian epithelial tumor specimens (including 147 malignant epithelial ovarian cancers, 30 borderline ovarian tumors, 16 benign ovarian epithelial tumors) and 11 normal ovarian epithelial tissues by immunohistochemistry. The results demonstrated widespread expression of Hh pathway molecules in ovarian tumors. However, there was no significant difference in the expression intensity of SHH among the four groups (P>0.05). Statistically significant differences were identified in the expression intensity of the SMO, PICH and GLI1 among groups (P
- Subjects :
- 0301 basic medicine
Cancer Research
endocrine system
endocrine system diseases
hedgehog glioma-associated oncogene 1 (GLI1)
03 medical and health sciences
Ovarian Epithelial Tumor
0302 clinical medicine
GLI1
medicine
ovarian epithelial tumor
hedgehog signaling pathway
smoothened (SMO)
Hedgehog
Oncogene
biology
Patched (PTCH)
business.industry
Cancer
chemoresistance
Articles
medicine.disease
Molecular medicine
Hedgehog signaling pathway
female genital diseases and pregnancy complications
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
biology.protein
Cancer research
Immunohistochemistry
business
Subjects
Details
- Language :
- English
- ISSN :
- 17921082 and 17921074
- Volume :
- 15
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Oncology Letters
- Accession number :
- edsair.doi.dedup.....a12046993802970cfd3797e24464c9b2