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Smoking and risk of treatment-induced neutralizing antibodies to interferon β-1a
- Source :
- Multiple Sclerosis Journal. 20:445-450
- Publication Year :
- 2013
- Publisher :
- SAGE Publications, 2013.
-
Abstract
- Background: Neutralizing antibodies (NAbs) to interferon β (IFNβ) products that develop during treatment are associated with a loss of clinical efficacy. Objectives: The aim of this study was to investigate the influence of smoking habits on the risk of developing NAbs to IFNβ, in the treatment of multiple sclerosis (MS). Methods: This report is based on 695 MS patients treated with IFNβ-1a, included in two Swedish case-control studies that collected information on smoking habits. Using logistic regression, the development of NAbs to IFNβ-1a among current smokers was compared with that of non-smokers, by calculating the odds ratio (OR) with a 95% confidence interval (CI). Results: Current smokers showed an increased risk of developing NAbs to IFNβ-1a, compared with non-smokers (OR 1.9; 95% CI 1.3–2.8; p = 0.002). There were no gender differences. We observed no association between past smoking and the risk of developing NAbs to IFNβ-1a. Conclusions: The finding that current smokers have an increased risk of developing NAbs to IFNβ-1a has implications, both for the practical care and the treatment of MS; it also provides an interesting perspective of the lungs as an immune-reactive organ, reacting upon irritation.
- Subjects :
- Adult
Male
medicine.medical_specialty
Multiple Sclerosis
Logistic regression
Risk Factors
Internal medicine
medicine
Humans
Immunologic Factors
Registries
Snuff
Neutralizing antibody
biology
business.industry
Multiple sclerosis
Smoking
Interferon-beta
Odds ratio
Middle Aged
medicine.disease
Antibodies, Neutralizing
Confidence interval
Interferon β 1a
Neurology
Immunology
biology.protein
Female
Neurology (clinical)
Antibody
business
Interferon beta-1a
Subjects
Details
- ISSN :
- 14770970 and 13524585
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Multiple Sclerosis Journal
- Accession number :
- edsair.doi.dedup.....a1279583f0fe68ad864dd9a812b6f270