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Gastrointestinal tolerance, growth and safety of a partly fermented formula with specific prebiotics in healthy infants: A double-blind, randomized, controlled trial
- Source :
- Nutrients, Vol 11, Iss 7, p 1530 (2019), Nutrients, Volume 11, Issue 7
- Publication Year :
- 2019
-
Abstract
- This study evaluated the effect of a partly fermented infant formula (using the bacterial strains Bifidobacterium breve C50 and Streptococcus thermophilus 065) with a specific prebiotic mixture (short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS<br />9:1)) on the incidence of gastrointestinal symptoms, stool characteristics, sleeping and crying behaviour, growth adequacy and safety. Two-hundred infants &le<br />28 days of age were assigned either to experimental infant formula containing 30% fermented formula and 0.8 g/100 mL scGOS/lcFOS or to non-fermented control infant formula without scGOS/lcFOS. A group of breastfed infants served as a reference. No relevant differences in parent-reported gastrointestinal symptoms were observed. Stool consistency was softer in the experimental versus control group with values closer to the breastfed reference group. Daily weight gain was equivalent for both formula groups (0.5 SD margins) with growth outcomes close to breastfed infants. No clinically relevant differences in adverse events were observed, apart from a lower investigator-reported prevalence of infantile colic in the experimental versus control group (1.1% vs. 8.7%<br />p &lt<br />0.02). Both study formulae are well-tolerated, support an adequate infant growth and are safe for use in healthy term infants. Compared to the control formula, the partly fermented formula with prebiotics induces stool consistencies closer to breastfed infants.
- Subjects :
- Male
Colic
Stool characteristic
medicine.medical_treatment
ved/biology.organism_classification_rank.species
crying
Oligosaccharides
Bifidobacterium breve
growth adequacy
Weight Gain
Gastroenterology
law.invention
Oligosaccharide
Feces
fluids and secretions
0302 clinical medicine
Child Development
Randomized controlled trial
law
Fermented Foods and Beverages
Streptococcus thermophilus
Age Factor
Prospective Studies
Prospective cohort study
Crying
Fermented formula
Gastrointestinal symptoms
Growth adequacy
ScGOS/lcFOS
Sleeping
Stool characteristics
Age Factors
Double-Blind Method
Female
Healthy Volunteers
Humans
Infant
Infant Behavior
Infant Formula
Infant Nutritional Physiological Phenomena
Italy
Nutritional Status
Sleep
Spain
Fermentation
Prebiotics
Nutrition and Dietetics
sleeping
food and beverages
stool characteristics
Healthy Volunteer
3. Good health
Nutritional Statu
030211 gastroenterology & hepatology
medicine.symptom
Fermented Foods
lcsh:Nutrition. Foods and food supply
Human
scGOS/lcFOS
medicine.medical_specialty
lcsh:TX341-641
Streptococcus thermophilu
Article
Infantile colic
03 medical and health sciences
030225 pediatrics
Internal medicine
Gastrointestinal symptom
medicine
Adverse effect
fermented formula
ved/biology
business.industry
Prebiotic
Fermented Foods and Beverage
medicine.disease
Prospective Studie
Infant formula
gastrointestinal symptoms
bacteria
Fece
business
Weight gain
Food Science
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Nutrients, Vol 11, Iss 7, p 1530 (2019), Nutrients, Volume 11, Issue 7
- Accession number :
- edsair.doi.dedup.....a176a9556328b6561e8df258f44c2a17