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Physiological and Metabolic Changes During the Transition from Hyperthyroidism to Euthyroidism in Graves' Disease
- Source :
- Thyroid : official journal of the American Thyroid Association. 26(10)
- Publication Year :
- 2016
-
Abstract
- The serum metabolomic profile and its relationship to physiological changes during hyperthyroidism and restoration to euthyroidism are not known. This study aimed to examine the physiological, adipokine, and metabolomic changes that occur when subjects with Graves' disease transition from hyperthyroidism to euthyroidism with medical treatment.Chinese women between 21 and 50 years of age and with newly diagnosed Graves' disease attending the endocrine outpatient clinics in a single institution were recruited between July 2012 and September 2014. All subjects were treated with thioamides to achieve euthyroidism. Clinical parameters (body weight, body composition via bioelectrical impedance analysis, resting energy expenditure and respiratory quotient via indirect calorimetry, and reported total energy intake via 24 h food diary), biochemical parameters (thyroid hormones, lipid profile, fasting insulin and glucose levels), serum leptin, adiponectin, and metabolomics profiles were measured during hyperthyroidism and repeated in early euthyroidism.Twenty four Chinese women with an average age of 36.3 ± 8.6 years were included in the study. The average duration of treatment that was required to reach euthyroidism for these subjects was 38 ± 16.3 weeks. There was a significant increase in body weight (52.6 ± 9.0 kg to 55.3 ± 9.4 kg; p 0.001) and fat mass (14.3 ± 6.9 kg to 16.8 ± 6.5 kg; p = 0.005). There was a reduction in resting energy expenditure corrected for weight (28.7 ± 4.0 kcal/kg to 21.5 ± 4.1 kcal/kg; p 0.001) and an increase in respiratory quotient (0.76 to 0.81; p = 0.037). Resting energy expenditure increased significantly with increasing free triiodothyronine levels (p = 0.007). Significant increases in total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were noted. There was no significant change in leptin levels, but adiponectin levels increased significantly (p = 0.018). Significant reductions in fasting C2, medium-chain, long-chain, and total acylcarnitines were observed, but no changes in the fat-free mass, branched chain amino acid levels, or insulin sensitivity during recovery from hyperthyroidism were noted.Serum metabolomics profile changes complemented the physiological changes observed during the transition from hyperthyroidism to euthyroidism. This study provides a comprehensive and integrated view of the changes in fuel metabolism and energy balance that occur following the treatment of hyperthyroidism.
- Subjects :
- 0301 basic medicine
Adult
endocrine system
medicine.medical_specialty
China
Outpatient Clinics, Hospital
endocrine system diseases
Carbimazole
Endocrinology, Diabetes and Metabolism
Graves' disease
Thyroid Gland
Adipokine
030209 endocrinology & metabolism
Weight Gain
Hyperthyroidism
03 medical and health sciences
Young Adult
0302 clinical medicine
Endocrinology
Hospitals, Urban
Antithyroid Agents
Asian People
Internal medicine
medicine
Outpatient clinic
Humans
Metabolomics
Resting energy expenditure
medicine.diagnostic_test
business.industry
Middle Aged
medicine.disease
Graves Disease
030104 developmental biology
Propylthiouracil
Basal metabolic rate
Female
Adiponectin
Basal Metabolism
Lipid profile
business
Energy Intake
Energy Metabolism
Bioelectrical impedance analysis
hormones, hormone substitutes, and hormone antagonists
Biomarkers
medicine.drug
Subjects
Details
- ISSN :
- 15579077
- Volume :
- 26
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Thyroid : official journal of the American Thyroid Association
- Accession number :
- edsair.doi.dedup.....a180b08cf9cd2b26a50ee856d13b75c9