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Is on-demand HIV pre-exposure prophylaxis a suitable tool for men who have sex with men who practice chemsex ? Results from a substudy of the ANRS-IPERGAY trial
- Source :
- Journal of Acquired Immune Deficiency Syndromes-JAIDS, Journal of Acquired Immune Deficiency Syndromes-JAIDS, 2018, 79 (2), pp.69-75. ⟨10.1097/QAI.0000000000001781⟩, Journal of Acquired Immune Deficiency Syndromes, Journal of Acquired Immune Deficiency Syndromes, Lippincott, Williams & Wilkins, 2018, 79 (2), pp.69-75. ⟨10.1097/QAI.0000000000001781⟩
- Publication Year :
- 2018
- Publisher :
- HAL CCSD, 2018.
-
Abstract
- International audience; Background: Chemsex-the use of psychoactive substances during sexual encounters-among men who have sex with men is a growing concern. On-demand HIV pre-exposure prophylaxis (PrEP) may be a suitable tool to prevent HIV transmission among "chemsexers." We used the open-label extension study of the ANRS-IPERGAY trial to describe chemsexers and their PrEP use. Methods: Among the 361 men who have sex with men enrolled in ANRS-IPERGAY's open-label extension study, we selected the 331 with available data on drug use. A 2-monthly web questionnaire on sociobehavioral data was used to compare sexual behaviors between questionnaires where chemsex was reported and those where it was not. Using a generalized estimating equation logistic regression, we studied whether practicing chemsex was associated with correct PrEP use. Results: Among the 331 participants, 30% reported chemsex practice at least once during follow-up and were considered chemsexers. Chemsex was reported in 16% of all questionnaires. Chemsexers were not significantly different from nonchemsexers regarding sociodemographic characteristics, although they reported greater use of anxiolytics and more sensation-seeking. Reporting chemsex was associated with more high-risk sexual practices and a higher perception of risk. After adjustment for other potential correlates, chemsex remained associated with correct PrEP use [odds ratio (95% confidence interval) = 2.24 (1.37 to 3.66)]. Conclusions: Our findings show that chemsexers were more likely to report high-risk sexual practices but also had a higher perception of risk. They were also more likely to use PrEP correctly when practicing chemsex. Consequently, PrEP may be a suitable tool to reduce HIV-risk transmission among chemsexers.
- Subjects :
- Adult
Male
medicine.medical_specialty
chemsex
HIV Infections
Logistic regression
Medication Adherence
law.invention
Men who have sex with men
03 medical and health sciences
Pre-exposure prophylaxis
0302 clinical medicine
Double-Blind Method
Randomized controlled trial
gay
prevention
law
Humans
Medicine
Pharmacology (medical)
030212 general & internal medicine
Homosexuality, Male
harm reduction
Generalized estimating equation
[SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Harm reduction
030505 public health
business.industry
HIV
Odds ratio
Middle Aged
PrEP
Risk perception
Infectious Diseases
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Family medicine
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Pre-Exposure Prophylaxis
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
0305 other medical science
business
Subjects
Details
- Language :
- English
- ISSN :
- 15254135 and 19447884
- Database :
- OpenAIRE
- Journal :
- Journal of Acquired Immune Deficiency Syndromes-JAIDS, Journal of Acquired Immune Deficiency Syndromes-JAIDS, 2018, 79 (2), pp.69-75. ⟨10.1097/QAI.0000000000001781⟩, Journal of Acquired Immune Deficiency Syndromes, Journal of Acquired Immune Deficiency Syndromes, Lippincott, Williams & Wilkins, 2018, 79 (2), pp.69-75. ⟨10.1097/QAI.0000000000001781⟩
- Accession number :
- edsair.doi.dedup.....a1a1d397c71801b68d76fa053ce0aaba