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Is on-demand HIV pre-exposure prophylaxis a suitable tool for men who have sex with men who practice chemsex ? Results from a substudy of the ANRS-IPERGAY trial

Authors :
Catherine Capitant
Luis Sagaon-Teyssier
Laurence Meyer
Cécile Tremblay
Daniela Rojas-Castro
Jean-Michel Molina
Lisa Fressard
Marie Suzan-Monti
Perrine Roux
Gilles Pialoux
Bruno Spire
Julie Chas
Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD)
Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Observatoire régional de la santé Provence-Alpes-Côte d'Azur [Marseille] (ORS PACA)
CHU Tenon [AP-HP]
Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
Institut de Recherche pour le Développement (IRD)
Essais Thérapeutiques et Maladies Infectieuses
Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Essais Therapeutiques et Infection Par Le Vih
Université de Montréal (UdeM)
Groupe de Recherche en Psychologie Sociale (GRePS)
Université Lumière - Lyon 2 (UL2)
AIDES [Pantin] (Siège national)
Institut Universitaire d'Hématologie (IUH)
Université Paris Diderot - Paris 7 (UPD7)
ANRS
Canadian HIV Trials Network
Fonds de Dotation Pierre Bergé pour la Prévention
Gilead Sciences donated the TDF-FTC and placebo used in the study, and partly funded for the pharmacokinetics analysis.
Bill and Melinda Gates Foundation
Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Sud - Paris 11 (UP11)
Lissalde, Claire
Source :
Journal of Acquired Immune Deficiency Syndromes-JAIDS, Journal of Acquired Immune Deficiency Syndromes-JAIDS, 2018, 79 (2), pp.69-75. ⟨10.1097/QAI.0000000000001781⟩, Journal of Acquired Immune Deficiency Syndromes, Journal of Acquired Immune Deficiency Syndromes, Lippincott, Williams & Wilkins, 2018, 79 (2), pp.69-75. ⟨10.1097/QAI.0000000000001781⟩
Publication Year :
2018
Publisher :
HAL CCSD, 2018.

Abstract

International audience; Background: Chemsex-the use of psychoactive substances during sexual encounters-among men who have sex with men is a growing concern. On-demand HIV pre-exposure prophylaxis (PrEP) may be a suitable tool to prevent HIV transmission among "chemsexers." We used the open-label extension study of the ANRS-IPERGAY trial to describe chemsexers and their PrEP use. Methods: Among the 361 men who have sex with men enrolled in ANRS-IPERGAY's open-label extension study, we selected the 331 with available data on drug use. A 2-monthly web questionnaire on sociobehavioral data was used to compare sexual behaviors between questionnaires where chemsex was reported and those where it was not. Using a generalized estimating equation logistic regression, we studied whether practicing chemsex was associated with correct PrEP use. Results: Among the 331 participants, 30% reported chemsex practice at least once during follow-up and were considered chemsexers. Chemsex was reported in 16% of all questionnaires. Chemsexers were not significantly different from nonchemsexers regarding sociodemographic characteristics, although they reported greater use of anxiolytics and more sensation-seeking. Reporting chemsex was associated with more high-risk sexual practices and a higher perception of risk. After adjustment for other potential correlates, chemsex remained associated with correct PrEP use [odds ratio (95% confidence interval) = 2.24 (1.37 to 3.66)]. Conclusions: Our findings show that chemsexers were more likely to report high-risk sexual practices but also had a higher perception of risk. They were also more likely to use PrEP correctly when practicing chemsex. Consequently, PrEP may be a suitable tool to reduce HIV-risk transmission among chemsexers.

Details

Language :
English
ISSN :
15254135 and 19447884
Database :
OpenAIRE
Journal :
Journal of Acquired Immune Deficiency Syndromes-JAIDS, Journal of Acquired Immune Deficiency Syndromes-JAIDS, 2018, 79 (2), pp.69-75. ⟨10.1097/QAI.0000000000001781⟩, Journal of Acquired Immune Deficiency Syndromes, Journal of Acquired Immune Deficiency Syndromes, Lippincott, Williams & Wilkins, 2018, 79 (2), pp.69-75. ⟨10.1097/QAI.0000000000001781⟩
Accession number :
edsair.doi.dedup.....a1a1d397c71801b68d76fa053ce0aaba