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Erythrocyte-rich thrombus aspirated from patients with ST-elevation myocardial infarction: association with oxidative stress and its impact on myocardial reperfusion
- Source :
- European heart journal, 33(12), 1480-1490. Oxford University Press
- Publication Year :
- 2012
-
Abstract
- Aims Recent studies have demonstrated that erythrocytes are a potential component in atheromatous lesions and thrombus formation in patients with ST-elevation myocardial infarction (STEMI). The purpose of this study was to determine the associations of red blood cell (RBC) component of coronary thrombi with oxidative stress and myocardial reperfusion. Methods and results Aspirated thrombi from 178 STEMI patients within 12 h of symptom onset were investigated immunohistochemically using antibodies against platelets, RBCs, fibrin, macrophages, and neutrophils [myeloperoxidase (MPO)]. The thrombi were divided into tertiles according to the percentage of glycophorin-A-positive area: low (glycophorin-A-positive area
- Subjects :
- Male
medicine.medical_specialty
Erythrocytes
medicine.medical_treatment
Myocardial Infarction
Myocardial Reperfusion
medicine.disease_cause
Coronary Angiography
Fibrin
Internal medicine
Angioplasty
medicine
Humans
Platelet
cardiovascular diseases
Myocardial infarction
Thrombus
Angioplasty, Balloon, Coronary
Thrombectomy
biology
Ventricular Remodeling
business.industry
Coronary Thrombosis
Middle Aged
medicine.disease
Red blood cell
Oxidative Stress
medicine.anatomical_structure
Treatment Outcome
Myeloperoxidase
Cardiology
biology.protein
Female
Cardiology and Cardiovascular Medicine
business
Oxidative stress
circulatory and respiratory physiology
Subjects
Details
- ISSN :
- 15229645 and 0195668X
- Volume :
- 33
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- European heart journal
- Accession number :
- edsair.doi.dedup.....a1a47e01c6ecd333bd847fa291610d32