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Prognostic significance of DNA ploidy pattern in osteosarcomas in association with chemotherapy
- Source :
- Cancer Letters. 137:27-33
- Publication Year :
- 1999
- Publisher :
- Elsevier BV, 1999.
-
Abstract
- In this study, we analysed the DNA ploidy of osteosarcomas at biopsy and attempted to clarify the relationship between DNA ploidy pattern and prognosis. Thirty patients with non-metastatic osteosarcoma of an extremity were studied. All underwent intensive chemotherapy with doxorubicin, cisplatin and methotrexate, in addition to wide tumor resection. DNA ploidy was detected by DNA cytofluorometry, using isolated and smeared cells of biopsied tumor tissue. Twelve tumors showed a diploid ploidy pattern and 18 showed a non-diploid pattern such as aneuploidy (15 tumors) and euploid-polyploidy (3 tumors). The event-free survival rate at 9 years was 63.5% in non-diploid osteosarcoma patients and 13.3% in diploid osteosarcoma patients. There was a statistically significant difference between the two groups (P = 0.0278). These results lead us to conclude that a non-diploid osteosarcoma may be more sensitive to chemotherapy than a diploid tumor.
- Subjects :
- Adult
G2 Phase
Male
musculoskeletal diseases
Cancer Research
Pathology
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Aneuploidy
Antineoplastic Agents
Bone Neoplasms
Biology
Disease-Free Survival
S Phase
Biopsy
medicine
Humans
Child
Survival rate
Aged
Cisplatin
Osteosarcoma
Chemotherapy
Ploidies
medicine.diagnostic_test
DNA, Neoplasm
Middle Aged
Prognosis
medicine.disease
Oncology
Female
Methotrexate
Ploidy
medicine.drug
Subjects
Details
- ISSN :
- 03043835
- Volume :
- 137
- Database :
- OpenAIRE
- Journal :
- Cancer Letters
- Accession number :
- edsair.doi.dedup.....a1aa0f4ca2b29aa7b7bc0b93636b49d6