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Extracellular matrix and growth factors in corneal wound healing

Extracellular matrix and growth factors in corneal wound healing

Authors :
Ilene K. Gipson
Tsutomu Inatomi
Source :
Current Opinion in Ophthalmology. 6:3-10
Publication Year :
1995
Publisher :
Ovid Technologies (Wolters Kluwer Health), 1995.

Abstract

Healing of corneal wounds is a complex process involving epithelial, keratocyte, and endothelial interactions that are affected by their associations with wound bed matrix and by cytokine availability and activation. The spectrum of possible cellular-matrix-growth factor interactions is indeed great and growing. Several of the significant contributions made during the past year include development of an organotypic organ culture model of the cornea that allows in vitro assembly of the epithelial extracellular matrix-anchoring complex, demonstration of epithelial synthesis of Bowman's layer collagens, demonstration of transforming growth factor-beta 2's inhibition of stromal cell collagenase synthesis, and demonstration of the paracrine pathway of keratinocyte growth factor action in the cornea.

Details

ISSN :
10408738
Volume :
6
Database :
OpenAIRE
Journal :
Current Opinion in Ophthalmology
Accession number :
edsair.doi.dedup.....a1d3b71bbf5afa71846eeaebdc9e8c38
Full Text :
https://doi.org/10.1097/00055735-199508000-00002