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Extracellular matrix and growth factors in corneal wound healing
Extracellular matrix and growth factors in corneal wound healing
- Source :
- Current Opinion in Ophthalmology. 6:3-10
- Publication Year :
- 1995
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1995.
-
Abstract
- Healing of corneal wounds is a complex process involving epithelial, keratocyte, and endothelial interactions that are affected by their associations with wound bed matrix and by cytokine availability and activation. The spectrum of possible cellular-matrix-growth factor interactions is indeed great and growing. Several of the significant contributions made during the past year include development of an organotypic organ culture model of the cornea that allows in vitro assembly of the epithelial extracellular matrix-anchoring complex, demonstration of epithelial synthesis of Bowman's layer collagens, demonstration of transforming growth factor-beta 2's inhibition of stromal cell collagenase synthesis, and demonstration of the paracrine pathway of keratinocyte growth factor action in the cornea.
- Subjects :
- Stromal cell
Cell Communication
Matrix (biology)
Organ culture
Epithelium
Cornea
Extracellular matrix
Paracrine signalling
chemistry.chemical_compound
Cell Adhesion
Extracellular
Animals
Humans
Medicine
Growth Substances
Wound Healing
business.industry
General Medicine
Extracellular Matrix
Cell biology
Ophthalmology
medicine.anatomical_structure
chemistry
Keratinocyte growth factor
business
Subjects
Details
- ISSN :
- 10408738
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Ophthalmology
- Accession number :
- edsair.doi.dedup.....a1d3b71bbf5afa71846eeaebdc9e8c38
- Full Text :
- https://doi.org/10.1097/00055735-199508000-00002