Back to Search
Start Over
Evaluation of intestinal damage biomarkers in calves with atresia coli
- Source :
- Journal of Veterinary Research, Vol 62, Iss 3, Pp 379-384 (2018), Journal of Veterinary Research
- Publication Year :
- 2018
- Publisher :
- Sciendo, 2018.
-
Abstract
- WOS: 000448623500021<br />PubMed: 30584620<br />Introduction: Intestinal obstruction such as atresia coli causes pathophysiological changes in gastrointestinal tissue due to the rise of intra-abdominal pressure. The aim of this study is to determine the intestinal damage with intestinal biomarkers in calves with atresia coli. Material and Methods: The study was conducted on 40 Holstein calves diagnosed with atresia coli with mild to moderate abdominal distention and 10 healthy Holstein calves which served as the control. Blood samples were collected from all calves, and then serum concentrations of intestinal biomarkers were estimated, namely intestinal fatty acid binding protein (IFABP), liver fatty acid binding protein (LFABP), trefoil factor 3 (TFF3), and intestinal alkaline phosphatase (IAP), using commercially available specific bovine ELISA kits. An automatic blood gas analyser was employed for determining the lactate concentration. Results: The concentrations of serum LFABP (P < 0.01), IFABP, TFF3, IAP, and blood lactate (P < 0.001) were significantly higher in calves with atresia coli than in healthy calves. Conclusion: The calves affected with atresia coli exhibited severe intestinal damage, and IFABP, LFABP, and TFF3 have significant diagnostic importance and play a useful role in determining the intestinal damage due to intestinal obstruction. High levels of IAP and lactate may serve as a signal for the development of intestinal injury.<br />Selcuk University, Scientific Research Project Office [15401147]<br />This study was supported by a grant received from the Selcuk University, Scientific Research Project Office (Project number: 15401147).
- Subjects :
- tff3
medicine.medical_specialty
congenital, hereditary, and neonatal diseases and abnormalities
lfabp
Veterinary medicine
atresia coli
Gastroenterology
calves
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Blood serum
Internal medicine
SF600-1100
medicine
otorhinolaryngologic diseases
Dairy cattle
General Veterinary
business.industry
Trefoil factor 3
030208 emergency & critical care medicine
ifabp
Pathophysiology
Lactic acid
medicine.anatomical_structure
chemistry
Blood chemistry
Abdomen
Alkaline phosphatase
030211 gastroenterology & hepatology
business
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 24508608 and 30584620
- Volume :
- 62
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of Veterinary Research
- Accession number :
- edsair.doi.dedup.....a1d5cf897229031dc4a66a6c2c1e7ed8