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Expression and clinical significance of SLP-2 in ovarian tumors
- Source :
- Oncology Letters
- Publication Year :
- 2019
- Publisher :
- D.A. Spandidos, 2019.
-
Abstract
- The expression and clinical significance of stomatin-like protein 2 (SLP-2) in ovarian tumors were investigated. A total of 280 cases of ovarian tissue specimens preserved from inpatients after surgical treatments in the Department of Oncology of Yidu Central Hospital of Weifang from April 2013 to May 2016 were collected, including 130 cases of malignant ovarian tumor tissue specimens (malignant tumor group), 75 cases of benign ovarian tumor tissue specimens (benign tumor group) and 75 cases of normal ovarian tissue specimens from bilateral ovariectomy for unilateral ovarian lesions (control group). Immunohistochemistry was used to detect the expression of SLP-2 protein in the three groups. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was utilized to detect the relative expression of SLP-2 mRNA in the three groups, and the relationship between SLP-2 and clinicopathological parameters of the ovarian cancer patients was analyzed. The patients with ovarian cancer were divided into the SLP-2 high-expression group and the SLP-2 low-expression group according to the median of SLP-2 relative expression. The survival of patients was analyzed using the Kaplan-Meier and Cox regression model. The results of immunohistochemistry showed that the positive expression rate of SLP-2 protein in the malignant tumor group was significantly higher than that in the benign tumor and control groups (P
- Subjects :
- 0301 basic medicine
Cancer Research
Pathology
medicine.medical_specialty
genetic structures
pathological differentiation
Benign tumor
Metastasis
03 medical and health sciences
Ovarian tumor
0302 clinical medicine
clinical stage
Medicine
Clinical significance
Oncogene
lymph node metastasis
business.industry
Cancer
Articles
medicine.disease
eye diseases
SLP-2
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
ovarian tumor
Immunohistochemistry
sense organs
business
Ovarian cancer
Subjects
Details
- Language :
- English
- ISSN :
- 17921082 and 17921074
- Volume :
- 17
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Oncology Letters
- Accession number :
- edsair.doi.dedup.....a1d67bba71fa9888cae5107356b91076