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mRNA-Based Protein Replacement Therapy for the Heart
- Source :
- Molecular Therapy
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Myocardial infarction (MI) and heart failure (HF) are the leading causes of death in the United States and in most other industrialized nations. MI leads to a massive loss of cardiomyocytes (CMs), which are replaced with non-CM cells, leading to scarring and, in most cases, HF. The adult mammalian heart has a low intrinsic regenerative capacity, mainly because of cell-cycle arrest in CMs. No effective treatment promoting heart regeneration is currently available. Recent efforts to use DNA-based or viral gene therapy approaches to induce cardiac regeneration post-MI or in HF conditions have encountered major challenges, mostly because of the poor and uncontrolled delivery of the introduced genes. Modified mRNA (modRNA) is a safe, non-immunogenic, efficient, transient, local, and controlled nucleic acid delivery system that can overcome the obstacles to DNA-based or viral approaches for cardiac gene delivery. We here review the use of modRNA in cardiac therapy, to induce cardioprotection and vascular or cardiac regeneration after MI. We discuss the current challenges in modRNA-based cardiac treatment, which will need to be overcome for the application of such treatment to ischemic heart disease.<br />Modified mRNA (modRNA) is a new technology in the field of somatic gene transfer in the heart. modRNA can be used to improve the condition of ischemic injury by inducing cardiac and cardiovascular regeneration and cardiac proliferation. In this issue of Molecular The.rapy, Magadum et al. review the use of modRNA-based protein replacement therapy for the heart.
- Subjects :
- Genetic enhancement
Myocardial Infarction
Review
Disease
Gene delivery
Transfection
Bioinformatics
03 medical and health sciences
Drug Delivery Systems
0302 clinical medicine
Protein replacement therapy
Drug Discovery
Genetics
medicine
Animals
Humans
Regeneration
Enzyme Replacement Therapy
Myocytes, Cardiac
RNA, Messenger
Myocardial infarction
Molecular Biology
030304 developmental biology
Heart Failure
Pharmacology
Cardioprotection
0303 health sciences
business.industry
Regeneration (biology)
mRNA therapy
cardiac regeneration
Genetic Therapy
medicine.disease
gene therapy
030220 oncology & carcinogenesis
Heart failure
Nanoparticles
Molecular Medicine
business
Subjects
Details
- ISSN :
- 15250016
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Molecular Therapy
- Accession number :
- edsair.doi.dedup.....a1d8e8a67037864d15aee45476a80c0a